Literature DB >> 2409666

Immunohistochemical characterization of an anti-epithelial monoclonal antibody (mAB lu-5).

J von Overbeck, C Stähli, F Gudat, H Carmann, C Lautenschlager, U Dürmüller, B Takacs, V Miggiano, T Staehelin, P U Heitz.   

Abstract

A mouse monoclonal antibody (mAB lu-5) was prepared using a lung cancer cell line as an antigen. The selected clone produces an IgG with a gamma-1 heavy chain and a kappa-light-chain. Immunohistochemical testing of mAB lu-5 on 117 normal tissue biopsies and 474 tumours revealed reactivity with an intracytoplasmic, formaldehyderesistant antigen present in most epithelial and mesothelial cells, but absent in mesenchymal cells. The antibody can therefore be used as a first order, pan-epithelial marker. It proved also useful for fast tumour diagnosis on frozen sections.

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Year:  1985        PMID： 2409666     DOI： 10.1007/bf00701324

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  20 in total

1.  A DIALYSIS TECHNIQUE FOR PREPARING FLUORESCENT ANTIBODY.

Authors:  H F CLARK; C C SHEPARD
Journal:  Virology       Date:  1963-08       Impact factor: 3.616

2.  Distribution of tissue polypeptide antigen (TPA) in normal human tissues: Immunohistochemical study on unfixed, methanol-, ethanol-, and formalin-fixed tissues.

Authors:  W B Nathrath; P Heidenkummer; V Björklund; B Björklund
Journal:  J Histochem Cytochem       Date:  1985-02       Impact factor: 2.479

3.  Immunohistochemical demonstration of hepatitis B core and surface antigens in paraffin sections.

Authors:  S N Huang
Journal:  Lab Invest       Date:  1975-07       Impact factor: 5.662

Review 4.  Immunohistochemistry of soft tissue tumors: progress and prospects.

Authors:  J J Brooks
Journal:  Hum Pathol       Date:  1982-11       Impact factor: 3.466

5.  The use of avidin-biotin interaction in immunoenzymatic techniques.

Authors:  J L Guesdon; T Ternynck; S Avrameas
Journal:  J Histochem Cytochem       Date:  1979-08       Impact factor: 2.479

6.  Immunoreactivity of paraffin-embedded normal tissues and mesenchymal tumors for smooth muscle myosin.

Authors:  L Donner; P de Lanerolle; J Costa
Journal:  Am J Clin Pathol       Date:  1983-11       Impact factor: 2.493

7.  Cytokeratins of normal epithelia and some neoplasms of the female genital tract.

Authors:  R Moll; R Levy; B Czernobilsky; P Hohlweg-Majert; G Dallenbach-Hellweg; W W Franke
Journal:  Lab Invest       Date:  1983-11       Impact factor: 5.662

8.  Monoclonal antibody to keratin filaments, specific for glandular epithelia and their tumors. Use in surgical pathology.

Authors:  F Ramaekers; A Huysmans; O Moesker; A Kant; P Jap; C Herman; P Vooijs
Journal:  Lab Invest       Date:  1983-09       Impact factor: 5.662

9.  Immunoperoxidase localization of prostate-specific antigen.

Authors:  B S Stein; S Vangore; R O Petersen; A R Kendall
Journal:  Am J Surg Pathol       Date:  1982-09       Impact factor: 6.394

10.  Antibodies to different intermediate filaments as histogenetic tumormarkers.

Authors:  A Schauer; M Osborn; K Weber; M Altmannsberger
Journal:  Acta Histochem Suppl       Date:  1984
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  36 in total

1.  Cytokeratin expression and early lens development.

Authors:  M Kasper; C Viebahn
Journal:  Anat Embryol (Berl)       Date:  1992-08

2.  Alveolar soft-part sarcoma of the uterine corpus: histological, immunocytochemical and ultrastructural study of a case.

Authors:  L Guillou; E Lamoureux; S Masse; J Costa
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1991

3.  Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study.

Authors:  C Doglioni; P Dell'Orto; G Zanetti; P Iuzzolino; G Coggi; G Viale
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1990

4.  Evidence of vascular differentiation in anaplastic tumours of the thyroid--an immunohistological study.

Authors:  F Eckert; U Schmid; F Gloor; C Hedinger
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1986

5.  A monoclonal antibody that detects myoepithelial cells in exocrine glands, basal cells in other epithelia and basal and suprabasal cells in certain hyperplastic tissues.

Authors:  J Caselitz; B Walther; J Wustrow; G Seifert; K Weber; M Osborn
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1986

6.  Immunohistochemistry in the diagnosis of malignant mesothelioma.

Authors:  M Pfaltz; B Odermatt; B Christen; J R Rüttner
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1987

7.  Pleomorphic adenomas, adenoid cystic carcinomas and adenolymphomas of salivary glands analysed by a monoclonal antibody against myoepithelial/basal cells. An immunohistochemical study.

Authors:  J Caselitz; M Osborn; K Hamper; J Wustrow; A Rauchfuss; K Weber
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1986

8.  Increase of calcium levels in epithelial cells induces translocation of calcium-binding proteins migration inhibitory factor-related protein 8 (MRP8) and MRP14 to keratin intermediate filaments.

Authors:  M Goebeler; J Roth; C van den Bos; G Ader; C Sorg
Journal:  Biochem J       Date:  1995-07-15       Impact factor: 3.857

9.  Villin--a marker of brush border differentiation and cellular origin in human renal cell carcinoma.

Authors:  H J Gröne; K Weber; U Helmchen; M Osborn
Journal:  Am J Pathol       Date:  1986-08       Impact factor: 4.307

10.  Expression of cytokeratins in granulosa cell tumors and ovarian carcinomas.

Authors:  G Gitsch; P Kohlberger; A Steiner; B Neumeister; G Breitenecker
Journal:  Arch Gynecol Obstet       Date:  1992       Impact factor: 2.344
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