Literature DB >> 2409205

Serological and immunochemical analysis of the products of a single HLA DR-alpha and DR-beta chain gene expressed in a mouse cell line after DNA-mediated cotransformation reveals that the beta chain carries a known supertypic specificity.

J Gorski, R Tosi, M Strubin, C Rabourdin-Combe, B Mach.   

Abstract

Using a mouse cell line transformed with and expressing a single HLA DR-alpha and DR-beta chain gene, we present evidence that the product of the DR-beta chain gene carries a supertypic determinant, BR3, previously defined by serology. The amino acid sequence of this beta chain gene is determined from the DNA sequence. Another DR-associated supertypic specificity defined by monoclonal antibody MCS7 was not encoded by this DR-beta chain gene. This provides formal proof that a supertypic specificity can be associated with a product of a distinct DR-beta locus. We propose that haplotypes sharing such specificities are evolutionarily related.

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Year:  1985        PMID： 2409205      PMCID： PMC2187690          DOI： 10.1084/jem.162.1.105

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  26 in total

1.  Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.

Authors:  M L Markert; P Cresswell
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

2.  Two populations of Ia-like molecules on a human B cell line.

Authors:  L A Lampson; R Levy
Journal:  J Immunol       Date:  1980-07       Impact factor: 5.422

3.  Distinct forms of both alpha and beta subunits are present in the human Ia molecular pool.

Authors:  R S Accolla; N Gross; S Carrel; G Corte
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

4.  HLA-DR typing by radioimmunoassay.

Authors:  R Tosi; N Tanigaki; D Centis; P L Rossi; G Alfano; G B Ferrara; D Pressman
Journal:  Transplantation       Date:  1980-04       Impact factor: 4.939

5.  A physical map of the DNA regions flanking the rabbit beta-globin gene.

Authors:  A J Jeffreys; R A Flavell
Journal:  Cell       Date:  1977-10       Impact factor: 41.582

6.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

7.  [Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen (author's transl)].

Authors:  H Kratzin; C Y Yang; H Götz; E Pauly; S Kölbel; G Egert; F P Thinnes; P Wernet; P Altevogt; N Hilschmann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1981-12

8.  Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.

Authors:  N Tanigaki; R Tosi; D Pressman; G B Ferrara
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

9.  Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.

Authors:  E O Long; C T Wake; J Gorski; B Mach
Journal:  EMBO J       Date:  1983       Impact factor: 11.598

10.  Immunological dissection of human Ia molecules.

Authors:  R Tosi; N Tanigaki; D Centis; G B Ferrara; D Pressman
Journal:  J Exp Med       Date:  1978-12-01       Impact factor: 14.307
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  18 in total

1.  Analysis of the DR beta chains from two DRw6 cell lines (WT46 and WT52): recombination in vivo may have generated new haplotypes.

Authors:  P J Knudsen; J McLean; J L Strominger
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

2.  Recognition of class II molecules by human T cells. I. Analysis of epitopes of DR and DQ molecules in a DRw11, DRw52, DQw3 haplotype.

Authors:  L K Myers; E J Ball; G Nuñez; P Stastny
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

3.  Serological recognition of HLA-DR allodeterminant corresponding to DNA sequence involved in gene conversion.

Authors:  C C Berte; N Tanigaki; R Tosi; J Gorski; B Mach
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

4.  Trans-species evolution of Mhc-DRB haplotype polymorphism in primates: organization of DRB genes in the chimpanzee.

Authors:  U Brändle; H Ono; V Vincek; D Klein; M Golubic; B Grahovac; J Klein
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

5.  Allelic variation in the DR subregion of the human major histocompatibility complex.

Authors:  J I Bell; D Denney; L Foster; T Belt; J A Todd; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

6.  Two DR beta allelic series defined by exon II-specific synthetic oligonucleotide genomic hybridization: a method of HLA typing?

Authors:  I Le Gall; P Millasseau; J Dausset; D Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

7.  Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8. II. Population analyses and blocking studies with monoclonal antibodies.

Authors:  S Rosen-Bronson; A H Johnson; R J Hartzman; D D Eckels
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

8.  Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic.

Authors:  J Gorski; P Rollini; B Mach
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

9.  Linkage map of three HLA-DR beta-chain genes: evidence for a recent duplication event.

Authors:  P Rollini; B Mach; J Gorski
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

10.  The evolutionary origin of the HLA-DR3 haplotype.

Authors:  V Vincek; D Klein; F Figueroa; V Hauptfeld; M Kasahara; C O'hUigin; B Mach; J Klein
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846
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