Literature DB >> 24088810

Detecting awareness after severe brain injury.

Davinia Fernández-Espejo1, Adrian M Owen.   

Abstract

Recent developments in functional neuroimaging have provided a number of new tools for assessing patients who clinically appear to be in a vegetative state. These techniques have been able to reveal awareness and even allow rudimentary communication in some patients who remain entirely behaviourally non-responsive. The implications of these results extend well beyond the immediate clinical and scientific findings to influencing legal proceedings, raising new ethical questions about the withdrawal of nutrition and hydration and providing new options for patients and families in that decision-making process. The findings have also motivated significant public discourse about the role of neuroscience research in society.

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Year:  2013        PMID: 24088810     DOI: 10.1038/nrn3608

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN: 1471-003X            Impact factor:   34.870


  61 in total

1.  Mental navigation in humans is processed in the anterior bank of the parieto-occipital sulcus.

Authors:  Tadashi Ino; Yumiko Inoue; Masato Kage; Syuichi Hirose; Tooru Kimura; Hidenao Fukuyama
Journal:  Neurosci Lett       Date:  2002-04-12       Impact factor: 3.046

2.  Bedside detection of awareness in the vegetative state: a cohort study.

Authors:  Damian Cruse; Srivas Chennu; Camille Chatelle; Tristan A Bekinschtein; Davinia Fernández-Espejo; John D Pickard; Steven Laureys; Adrian M Owen
Journal:  Lancet       Date:  2011-11-09       Impact factor: 79.321

3.  Considerations and costs of disclosing study findings to research participants.

Authors:  Conrad V Fernandez; Chris Skedgel; Charles Weijer
Journal:  CMAJ       Date:  2004-04-27       Impact factor: 8.262

4.  Persistent vegetative state after brain damage. A syndrome in search of a name.

Authors:  B Jennett; F Plum
Journal:  Lancet       Date:  1972-04-01       Impact factor: 79.321

Review 5.  Coma and consciousness: paradigms (re)framed by neuroimaging.

Authors:  Steven Laureys; Nicholas D Schiff
Journal:  Neuroimage       Date:  2011-12-27       Impact factor: 6.556

6.  Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness.

Authors:  M R Coleman; M H Davis; J M Rodd; T Robson; A Ali; A M Owen; J D Pickard
Journal:  Brain       Date:  2009-09       Impact factor: 13.501

7.  Executive functions in the absence of behavior: functional imaging of the minimally conscious state.

Authors:  Martin M Monti; Martin R Coleman; Adrian M Owen
Journal:  Prog Brain Res       Date:  2009       Impact factor: 2.453

Review 8.  Medical aspects of the persistent vegetative state (1).

Authors: 
Journal:  N Engl J Med       Date:  1994-05-26       Impact factor: 91.245

9.  Voluntary brain processing in disorders of consciousness.

Authors:  C Schnakers; F Perrin; M Schabus; S Majerus; D Ledoux; P Damas; M Boly; A Vanhaudenhuyse; M-A Bruno; G Moonen; S Laureys
Journal:  Neurology       Date:  2008-11-11       Impact factor: 9.910

10.  A survey on self-assessed well-being in a cohort of chronic locked-in syndrome patients: happy majority, miserable minority.

Authors:  Marie-Aurélie Bruno; Jan L Bernheim; Didier Ledoux; Frédéric Pellas; Athena Demertzi; Steven Laureys
Journal:  BMJ Open       Date:  2011-02-23       Impact factor: 2.692

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  42 in total

1.  Can time-resolved NIRS provide the sensitivity to detect brain activity during motor imagery consistently?

Authors:  Androu Abdalmalak; Daniel Milej; Mamadou Diop; Mahsa Shokouhi; Lorina Naci; Adrian M Owen; Keith St Lawrence
Journal:  Biomed Opt Express       Date:  2017-03-13       Impact factor: 3.732

2.  Altered Protein Profiling in Tears from Patients in a Traumatic Vegetative State.

Authors:  Hai Zou; Wangxiao Bao; Benyan Luo
Journal:  Neurosci Bull       Date:  2018-07-23       Impact factor: 5.203

3.  Disorders of consciousness: Diagnostic accuracy of brain imaging in the vegetative state.

Authors:  Adrian M Owen
Journal:  Nat Rev Neurol       Date:  2014-06-17       Impact factor: 42.937

4.  Improving diagnosis and prognosis in disorders of consciousness.

Authors:  Adrian M Owen
Journal:  Brain       Date:  2020-04-01       Impact factor: 13.501

Review 5.  Prognostication, Ethical Issues, and Palliative Care in Disorders of Consciousness.

Authors:  Adeline L Goss; Claire J Creutzfeldt
Journal:  Neurol Clin       Date:  2022-02       Impact factor: 3.806

6.  DBS and Autonomy: Clarifying the Role of Theoretical Neuroethics.

Authors:  Peter Zuk; Gabriel Lázaro-Muñoz
Journal:  Neuroethics       Date:  2019-07-25       Impact factor: 1.427

7.  A common neural code for similar conscious experiences in different individuals.

Authors:  Lorina Naci; Rhodri Cusack; Mimma Anello; Adrian M Owen
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-15       Impact factor: 11.205

Review 8.  Risk, diagnostic error, and the clinical science of consciousness.

Authors:  Andrew Peterson; Damian Cruse; Lorina Naci; Charles Weijer; Adrian M Owen
Journal:  Neuroimage Clin       Date:  2015-02-20       Impact factor: 4.881

9.  The Potential Role of fNIRS in Evaluating Levels of Consciousness.

Authors:  Androu Abdalmalak; Daniel Milej; Loretta Norton; Derek B Debicki; Adrian M Owen; Keith St Lawrence
Journal:  Front Hum Neurosci       Date:  2021-07-08       Impact factor: 3.169

10.  Acknowledging awareness: informing families of individual research results for patients in the vegetative state.

Authors:  Mackenzie Graham; Charles Weijer; Andrew Peterson; Lorina Naci; Damian Cruse; Davinia Fernández-Espejo; Laura Gonzalez-Lara; Adrian M Owen
Journal:  J Med Ethics       Date:  2014-07-30       Impact factor: 2.903

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