Literature DB >> 24088695

Synthesis and biological evaluation of thiophene-C-glucosides as sodium-dependent glucose cotransporter 2 inhibitors.

Shigeki Sakamaki1, Eiji Kawanishi, Yuichi Koga, Yasuo Yamamoto, Chiaki Kuriyama, Yasuaki Matsushita, Kiichiro Ueta, Sumihiro Nomura.   

Abstract

The synthesis and structure-activity relationship (SAR) of thiophene-C-glucosides have been explored, and the human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitory activities and rat urinary glucose excretion (UGE) effects of 3a-f were evaluated. As a result, they showed good hSGLT2 inhibitory activities and rat UGE effects. In particular, the chlorothiophene derivative 3f showed remarkable inhibitory activity against hSGLT2.

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Year:  2013        PMID： 24088695     DOI： 10.1248/cpb.c13-00407

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

1.  Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate.

Authors:  Yahia Nasser Mabkhot; Nahed Ahmed Kaal; Seham Alterary; Salem S Al-Showiman; Thoraya A Farghaly; Mohammad S Mubarak
Journal:  Chem Cent J       Date:  2017-08-03       Impact factor: 4.215

2.  Synthesis of novel Schiff bases using 2-Amino-5-(3-fluoro-4-methoxyphenyl)thiophene-3-carbonitrile and 1,3-Disubstituted pyrazole-4-carboxaldehydes derivatives and their antimicrobial activity.

Authors:  Divyaraj Puthran; Boja Poojary; Nikil Purushotham; Nandam Harikrishna; Soukhyarani Gopal Nayak; Vinuta Kamat
Journal:  Heliyon       Date:  2019-08-26

3.  Dual-Target Compounds against Type 2 Diabetes Mellitus: Proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors.

Authors:  Ádám Sipos; Eszter Szennyes; Nikolett Éva Hajnal; Sándor Kun; Katalin E Szabó; Karen Uray; László Somsák; Tibor Docsa; Éva Bokor
Journal:  Pharmaceuticals (Basel)       Date:  2021-04-15
  3 in total

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