Literature DB >> 24084861

TSC on the peroxisome controls mTORC1.

Don Benjamin1, Michael N Hall.   

Abstract

mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.

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Year:  2013        PMID： 24084861     DOI： 10.1038/ncb2849

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  10 in total

1.  Localization of Rheb to the endomembrane is critical for its signaling function.

Authors:  Claudia Buerger; Ben DeVries; Vuk Stambolic
Journal:  Biochem Biophys Res Commun       Date:  2006-04-19       Impact factor: 3.575

2.  The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Authors:  Yasemin Sancak; Timothy R Peterson; Yoav D Shaul; Robert A Lindquist; Carson C Thoreen; Liron Bar-Peled; David M Sabatini
Journal:  Science       Date:  2008-05-22       Impact factor: 47.728

3.  Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.

Authors:  Frank Wippich; Bernd Bodenmiller; Maria Gustafsson Trajkovska; Stefanie Wanka; Ruedi Aebersold; Lucas Pelkmans
Journal:  Cell       Date:  2013-02-14       Impact factor: 41.582

4.  Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Authors:  Yasemin Sancak; Liron Bar-Peled; Roberto Zoncu; Andrew L Markhard; Shigeyuki Nada; David M Sabatini
Journal:  Cell       Date:  2010-04-08       Impact factor: 41.582

5.  Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology.

Authors:  Charles Betz; Daniele Stracka; Cristina Prescianotto-Baschong; Maud Frieden; Nicolas Demaurex; Michael N Hall
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-12       Impact factor: 11.205

6.  ATM activation by oxidative stress.

Authors:  Zhi Guo; Sergei Kozlov; Martin F Lavin; Maria D Person; Tanya T Paull
Journal:  Science       Date:  2010-10-22       Impact factor: 47.728

Review 7.  Amino acid signalling upstream of mTOR.

Authors:  Jenna L Jewell; Ryan C Russell; Kun-Liang Guan
Journal:  Nat Rev Mol Cell Biol       Date:  2013-01-30       Impact factor: 94.444

8.  ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.

Authors:  Angela Alexander; Sheng-Li Cai; Jinhee Kim; Adrian Nanez; Mustafa Sahin; Kirsteen H MacLean; Ken Inoki; Kun-Liang Guan; Jianjun Shen; Maria D Person; Donna Kusewitt; Gordon B Mills; Michael B Kastan; Cheryl Lyn Walker
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-16       Impact factor: 11.205

Review 9.  Peroxisome assembly: matrix and membrane protein biogenesis.

Authors:  Changle Ma; Gaurav Agrawal; Suresh Subramani
Journal:  J Cell Biol       Date:  2011-04-04       Impact factor: 10.539

10.  A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.

Authors:  Jiangwei Zhang; Jinhee Kim; Angela Alexander; Shengli Cai; Durga Nand Tripathi; Ruhee Dere; Andrew R Tee; Jacqueline Tait-Mulder; Alessia Di Nardo; Juliette M Han; Erica Kwiatkowski; Elaine A Dunlop; Kayleigh M Dodd; Rebecca D Folkerth; Phyllis L Faust; Michael B Kastan; Mustafa Sahin; Cheryl Lyn Walker
Journal:  Nat Cell Biol       Date:  2013-08-18       Impact factor: 28.824
  10 in total
  10 in total

1.  Squamosamide derivative FLZ protected tyrosine hydroxylase function in a chronic MPTP/probenecid mouse model of Parkinson's disease.

Authors:  Xiu-Qi Bao; Liang-Yu Wu; Xiao-Liang Wang; Hua Sun; Dan Zhang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-02-13       Impact factor: 3.000

Review 2.  Growing knowledge of the mTOR signaling network.

Authors:  Kezhen Huang; Diane C Fingar
Journal:  Semin Cell Dev Biol       Date:  2014-09-19       Impact factor: 7.727

Review 3.  Translational reprogramming in cellular stress response.

Authors:  Botao Liu; Shu-Bing Qian
Journal:  Wiley Interdiscip Rev RNA       Date:  2013-12-23       Impact factor: 9.957

Review 4.  Where is mTOR and what is it doing there?

Authors:  Charles Betz; Michael N Hall
Journal:  J Cell Biol       Date:  2013-11-25       Impact factor: 10.539

Review 5.  Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells.

Authors:  Yao Yao; Edith Jones; Ken Inoki
Journal:  Biomolecules       Date:  2017-07-07

Review 6.  mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review.

Authors:  Thomas Weichhart
Journal:  Gerontology       Date:  2017-12-01       Impact factor: 5.140

Review 7.  Regulation of autophagy by amino acids and MTOR-dependent signal transduction.

Authors:  Alfred J Meijer; Séverine Lorin; Edward F Blommaart; Patrice Codogno
Journal:  Amino Acids       Date:  2014-06-01       Impact factor: 3.520

8.  ATM functions at the peroxisome to induce pexophagy in response to ROS.

Authors:  Jiangwei Zhang; Durga Nand Tripathi; Ji Jing; Angela Alexander; Jinhee Kim; Reid T Powell; Ruhee Dere; Jacqueline Tait-Mulder; Ji-Hoon Lee; Tanya T Paull; Raj K Pandita; Vijaya K Charaka; Tej K Pandita; Michael B Kastan; Cheryl Lyn Walker
Journal:  Nat Cell Biol       Date:  2015-09-07       Impact factor: 28.824

Review 9.  Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot.

Authors:  Deborah C I Goberdhan; Clive Wilson; Adrian L Harris
Journal:  Cell Metab       Date:  2016-04-12       Impact factor: 27.287

Review 10.  Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention.

Authors:  Xudong Zhu; Zhiyang Chen; Weiyan Shen; Gang Huang; John M Sedivy; Hu Wang; Zhenyu Ju
Journal:  Signal Transduct Target Ther       Date:  2021-06-28
  10 in total

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