Literature DB >> 2408448

Effect of calmodulin inhibitors on histamine secretion from mast cells.

P T Peachell, F L Pearce.   

Abstract

Histamine secretion from isolated peritoneal mast cells was inhibited by a number of calmodulin antagonists. The characteristics of the inhibition were consistent with an action after calcium influx. The rank order of potency of the compounds correlated approximately with their reported anti-calmodulin activity. These data provide tentative support for the involvement of calmodulin in stimulus-secretion coupling in the mast cell.

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Year:  1985        PMID： 2408448     DOI： 10.1007/bf01999642

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

Review 1.  Possible role of calmodulin in human inflammatory reactions.

Authors:  G Marone; M Columbo; S Poto; P Bianco; G Torella; M Condorelli
Journal:  Monogr Allergy       Date:  1983

2.  On the calcium receptor activating exocytosis: inhibitory effects of calmodulin-interacting drugs on rat mast cells.

Authors:  W W Douglas; E F Nemeth
Journal:  J Physiol       Date:  1982-02       Impact factor: 5.182

Review 3.  Calcium and histamine secretion from mast cells.

Authors:  F L Pearce
Journal:  Prog Med Chem       Date:  1982

4.  Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.

Authors:  W C Prozialeck; B Weiss
Journal:  J Pharmacol Exp Ther       Date:  1982-09       Impact factor: 4.030

5.  Characteristics of histamine secretion from rat peritoneal mast cells sensitized to the nematode Nippostrongylus brasiliensis.

Authors:  J R White; F L Pearce
Journal:  Immunology       Date:  1982-06       Impact factor: 7.397

6.  Lanthanides are transported by ionophore A23187 and mimic calcium in the histamine secretion process.

Authors:  M Amellal; Y Landry
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739

7.  Cyclic AMP levels during stimulation and inhibition of histamine release from rat mast cells by the calmodulin inhibitor trifluoperazine.

Authors:  P E Alm
Journal:  Int Arch Allergy Appl Immunol       Date:  1983
  7 in total
  4 in total

1.  Role of lysosomal and cytosolic pH in the regulation of macrophage lysosomal enzyme secretion.

Authors:  H Tapper; R Sundler
Journal:  Biochem J       Date:  1990-12-01       Impact factor: 3.857

2.  The role of a Ca2+/calmodulin dependent plasma membrane Ca2+ channel during concanavalin A activation of MC9 mast cells.

Authors:  A Gulbenkian; J Myers; R W Egan; M I Siegel
Journal:  Agents Actions       Date:  1987-10

3.  Divalent cation dependence of the inhibition by phenothiazines of mediator release from mast cells.

Authors:  P T Peachell; F L Pearce
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739

4.  Effects of calmodulin antagonists on human adenoidal mast cells.

Authors:  S Bent; U Braam; W Schmutzler
Journal:  Agents Actions       Date:  1990-04
  4 in total

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