| Literature DB >> 24084320 |
Da-Ke Zhao1, Hong-Lian Ai2, Shu-Hui Zi2, Li-Mei Zhang2, Sheng-Chao Yang2, Hua-Chun Guo2, Yong Shen3, Yan-Ping Chen2, Ji-Jun Chen4.
Abstract
Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg.Entities:
Keywords: Aconitum weixiense; Analgesic activity; Diterpenoid alkaloids; Ranunculaceae; Weisaconitines A–D
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Year: 2013 PMID： 24084320 DOI： 10.1016/j.fitote.2013.09.013
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882