Literature DB >> 2408272

Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene.

P J Farnham, J M Abrams, R T Schimke.   

Abstract

We have characterized a transcription unit in the 5' flanking region of the mouse gene encoding dihydrofolate reductase (EC 1.5.1.3) that is oriented in the opposite direction to that of dihydrofolate reductase transcription. These opposite-strand RNAs are 180-240 nucleotides long, differing in length at their 5' ends. They are abundant in nuclear RNA and are not polyadenylylated. We suggest that the promoter region of the dihydrofolate reductase gene functions in a bidirectional manner to produce both these RNAs and dihydrofolate reductase mRNAs.

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Year:  1985        PMID： 2408272      PMCID： PMC397917          DOI： 10.1073/pnas.82.12.3978

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors:  A J Berk; P A Sharp
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

2.  Prolonged incubation in calcium chloride improves the competence of Escherichia coli cells.

Authors:  M Dagert; S D Ehrlich
Journal:  Gene       Date:  1979-05       Impact factor: 3.688

3.  Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping.

Authors:  J Favaloro; R Treisman; R Kamen
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

4.  Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region.

Authors:  S L McKnight; E R Gavis; R Kingsbury; R Axel
Journal:  Cell       Date:  1981-08       Impact factor: 41.582

Review 5.  Organization and expression of eucaryotic split genes coding for proteins.

Authors:  R Breathnach; P Chambon
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

6.  Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.

Authors:  R Grosschedl; M L Birnstiel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

7.  Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogenity at the mRNA 5' end.

Authors:  C C Baker; J Herisse; G Courtois; F Galibert; E Ziff
Journal:  Cell       Date:  1979-10       Impact factor: 41.582

8.  Size heterogeneity in the 3' end of dihydrofolate reductase messenger RNAs in mouse cells.

Authors:  D R Setzer; M McGrogan; J H Nunberg; R T Schimke
Journal:  Cell       Date:  1980-11       Impact factor: 41.582

9.  Simian virus 40 guanine-cytosine-rich sequences function as independent transcriptional control elements in vitro.

Authors:  H Mishoe; J N Brady; M Radonovich; N P Salzman
Journal:  Mol Cell Biol       Date:  1984-12       Impact factor: 4.272

10.  Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

Authors:  G Urlaub; L A Chasin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205
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  48 in total

1.  A plant virus satellite RNA exhibits a significant sequence complementarity to a chloroplast tRNA.

Authors:  C Masuta; S Kuwata; T Matzuzaki; Y Takanami; A Koiwai
Journal:  Nucleic Acids Res       Date:  1992-06-11       Impact factor: 16.971

2.  Transcriptional control of the invariant chain gene involves promoter and enhancer elements common to and distinct from major histocompatibility complex class II genes.

Authors:  L Zhu; P P Jones
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

3.  Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.

Authors:  H Saito; T Koyama; K Georgopoulos; H Clevers; W G Haser; T LeBien; S Tonegawa; C Terhorst
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

4.  N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.

Authors:  G W Krystal; B C Armstrong; J F Battey
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

5.  The U3 region is not necessary for 3' end formation of spleen necrosis virus RNA.

Authors:  K Iwasaki; H M Temin
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

6.  Characterization of an unique RNA initiated immediately upstream from human alpha 1 globin gene in vivo and in vitro: polymerase II-dependence, tissue specificity, and subcellular location.

Authors:  J Hess; C Perez-Stable; A Deisseroth; C K Shen
Journal:  Nucleic Acids Res       Date:  1985-09-11       Impact factor: 16.971

7.  Determinator-inhibitor pairs as a mechanism for threshold setting in development: a possible function for pseudogenes.

Authors:  J R McCarrey; A D Riggs
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

8.  Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site.

Authors:  A L Means; P J Farnham
Journal:  Mol Cell Biol       Date:  1990-02       Impact factor: 4.272

9.  Minor transcription initiation events indicate that both human mitochondrial promoters function bidirectionally.

Authors:  D D Chang; J E Hixson; D A Clayton
Journal:  Mol Cell Biol       Date:  1986-01       Impact factor: 4.272

10.  Murine dihydrofolate reductase transcripts through the cell cycle.

Authors:  P J Farnham; R T Schimke
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272
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