Raymond O Beirne1. 1. Vision Science Research Group, School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK, r.beirne@ulster.ac.uk.
Abstract
PURPOSE: To investigate the relationship between the central spatial profile of macular pigment optical density (MPOD) and increasing age in normal eyes. METHODS: Ninety-eight individuals (aged 19-71 years) with good visual acuity, free from ocular disease, and with clear ocular media participated. MPOD was measured at 0.25, 0.50, 1.00, and 1.75° eccentricity from the foveal centre using a heterochromatic flicker photometry based densitometer instrument. RESULTS: Linear regression analysis revealed that there was no statistically significant association between MPOD and increasing age for the group as a whole at 0.25, 0.50, and 1.00° eccentricity (p > 0.05 for all eccentricities). There was a small but statistically significant positive association between increasing age and MPOD at 1.75° eccentricity (p = 0.020), but age only accounted for 6 % of the variation in MPOD values. Fifteen percent of all participants had a non-exponential MPOD spatial profile. CONCLUSION: There was no statistically significant relationship between MPOD and increasing age for three of the four locations measured. A significant proportion of individuals show an atypical MPOD spatial profile, indicating that studies on MPOD should ideally report information on the MPOD spatial profile rather than estimates from only one retinal location.
PURPOSE: To investigate the relationship between the central spatial profile of macular pigment optical density (MPOD) and increasing age in normal eyes. METHODS: Ninety-eight individuals (aged 19-71 years) with good visual acuity, free from ocular disease, and with clear ocular media participated. MPOD was measured at 0.25, 0.50, 1.00, and 1.75° eccentricity from the foveal centre using a heterochromatic flicker photometry based densitometer instrument. RESULTS: Linear regression analysis revealed that there was no statistically significant association between MPOD and increasing age for the group as a whole at 0.25, 0.50, and 1.00° eccentricity (p > 0.05 for all eccentricities). There was a small but statistically significant positive association between increasing age and MPOD at 1.75° eccentricity (p = 0.020), but age only accounted for 6 % of the variation in MPOD values. Fifteen percent of all participants had a non-exponential MPOD spatial profile. CONCLUSION: There was no statistically significant relationship between MPOD and increasing age for three of the four locations measured. A significant proportion of individuals show an atypical MPOD spatial profile, indicating that studies on MPOD should ideally report information on the MPOD spatial profile rather than estimates from only one retinal location.
Authors: James Loughman; Mukunda C Akkali; Stephen Beatty; Grainne Scanlon; Peter A Davison; Veronica O'Dwyer; Tom Cantwell; Philip Major; Jim Stack; John M Nolan Journal: Vision Res Date: 2010-04-13 Impact factor: 1.886
Authors: Eithne E Connolly; Stephen Beatty; David I Thurnham; James Loughman; Alan N Howard; Jim Stack; John M Nolan Journal: Curr Eye Res Date: 2010-04 Impact factor: 2.424
Authors: Fábio B Daga; Nara G Ogata; Felipe A Medeiros; Rachel Moran; Jeffrey Morris; Linda M Zangwill; Robert N Weinreb; John M Nolan Journal: Invest Ophthalmol Vis Sci Date: 2018-09-04 Impact factor: 4.799