Literature DB >> 24077767

Have We Hatched the Addiction Egg: Reward Deficiency Syndrome Solution System™

Bw Downs1, M Oscar-Berman, Rl Waite, Ma Madigan, J Giordano, T Beley, S Jones, T Simpatico, M Hauser, J Borsten, F Marcelo, Er Braverman, R Lohmann, K Dushaj, M Helman, D Barh, St Schoenthaler, D Han, K Blum.   

Abstract

This article co-authored by a number of scientists, ASAM physicians, clinicians, treatment center owners, geneticists, neurobiologists, psychologists, social workers, criminologists, nurses, nutritionist, and students, is dedicated to all the people who have lost loved ones in substance-abuse and "reward deficiency syndrome" related tragedies. Why are we failing at reducing the incidence of 'Bad Behaviors'? Are we aiming at the wrong treatment targets for behavioral disorders? We are proposing a paradigm shift and calling it "Reward Deficiency Solution System" providing evidence for its adoption.

Entities:  

Keywords:  Addiction; Reward Deficiency Syndrome (RDS) dopamine; Standard of Care

Year:  2013        PMID： 24077767      PMCID： PMC3783340          DOI： 10.4172/2157-7412.1000136

Source DB:  PubMed          Journal:  J Genet Syndr Gene Ther        ISSN： 2157-7412


  14 in total

Review 1.  Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.

Authors:  A T McLellan; D C Lewis; C P O'Brien; H D Kleber
Journal:  JAMA       Date:  2000-10-04       Impact factor: 56.272

2.  The process addictions and the new ASAM definition of addiction.

Authors:  David E Smith
Journal:  J Psychoactive Drugs       Date:  2012 Jan-Mar

3.  Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism.

Authors:  E P Noble; K Blum; T Ritchie; A Montgomery; P J Sheridan
Journal:  Arch Gen Psychiatry       Date:  1991-07

Review 4.  The addictive brain: all roads lead to dopamine.

Authors:  Kenneth Blum; Amanda L C Chen; John Giordano; Joan Borsten; Thomas J H Chen; Mary Hauser; Thomas Simpatico; John Femino; Eric R Braverman; Debmalya Barh
Journal:  J Psychoactive Drugs       Date:  2012 Apr-Jun

5.  Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by a neuroadaptagen: proposing an addiction candidate gene panel map.

Authors:  Thomas J H Chen; Kenneth Blum; Amanda L C Chen; Abdalla Bowirrat; William B Downs; Margret A Madigan; Roger L Waite; John A Bailey; Mallory Kerner; Swetha Yeldandi; Neil Majmundar; John Giordano; Siohban Morse; David Miller; Frank Fornari; Eric R Braverman
Journal:  J Psychoactive Drugs       Date:  2011 Apr-Jun

6.  Weight gain is associated with reduced striatal response to palatable food.

Authors:  Eric Stice; Sonja Yokum; Kenneth Blum; Cara Bohon
Journal:  J Neurosci       Date:  2010-09-29       Impact factor: 6.167

Review 7.  The D2 dopamine receptor gene as a determinant of reward deficiency syndrome.

Authors:  K Blum; P J Sheridan; R C Wood; E R Braverman; T J Chen; J G Cull; D E Comings
Journal:  J R Soc Med       Date:  1996-07       Impact factor: 18.000

8.  Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

Authors: 
Journal:  Lancet       Date:  2013-02-28       Impact factor: 79.321

9.  Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males.

Authors:  Fleur Zijlstra; Jan Booij; Wim van den Brink; Ingmar H A Franken
Journal:  Eur Neuropsychopharmacol       Date:  2008-04       Impact factor: 4.600

10.  Nutrigenomic targeting of carbohydrate craving behavior: can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map?

Authors:  B William Downs; Amanda L C Chen; Thomas J H Chen; Roger L Waite; Eric R Braverman; Mallory Kerner; Dasha Braverman; Patrick Rhoades; Thomas J Prihoda; Tomas Palomo; Marlene Oscar-Berman; Jeffrey Reinking; Seth H Blum; Nicholas A DiNubile; H H Liu; Kenneth Blum
Journal:  Med Hypotheses       Date:  2009-05-17       Impact factor: 1.538
View more
  11 in total

1.  THE BENEFITS OF CUSTOMIZED DNA DIRECTED NUTRITION TO BALANCE THE BRAIN REWARD CIRCUITRY AND REDUCE ADDICTIVE BEHAVIORS.

Authors:  Kenneth Blum; B W Downs; Kristina Dushaj; Mona Li; Eric R Braverman; Lyle Fried; Roger Waite; Zsolt Demotrovics; Rajendra D Badgaiyan
Journal:  Precis Med (Bangalore)       Date:  2016-08-01

2.  Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

Authors:  Kenneth Blum; Edward J Modestino; Rajendra D Badgaiyan; David Baron; Panayotis K Thanos; Igor Elman; David Siwicki; Marcelo Febo; Mark S Gold
Journal:  EC Psychol Psychiatr       Date:  2018-07-30

3.  Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens Dopamine Release.

Authors:  Fiona D Zeeb; Ashlie D Soko; Xiaodong Ji; Paul J Fletcher
Journal:  Neuropsychopharmacology       Date:  2016-01-19       Impact factor: 7.853

Review 4.  Neuroscience of Internet Pornography Addiction: A Review and Update.

Authors:  Todd Love; Christian Laier; Matthias Brand; Linda Hatch; Raju Hajela
Journal:  Behav Sci (Basel)       Date:  2015-09-18

Review 5.  Dopamine and glucose, obesity, and reward deficiency syndrome.

Authors:  Kenneth Blum; Panayotis K Thanos; Mark S Gold
Journal:  Front Psychol       Date:  2014-09-17

6.  Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS).

Authors:  Kenneth Blum; Marlene Oscar-Berman; Zsolt Demetrovics; Debmalya Barh; Mark S Gold
Journal:  Mol Neurobiol       Date:  2014-05-31       Impact factor: 5.590

7.  Neurophysiological Measures and Alcohol Use Disorder (AUD): Hypothesizing Links between Clinical Severity Index and Molecular Neurobiological Patterns.

Authors:  Mario Vitali; Carmen Napolitano; Marlene Oscar Berman; Simona Flamminii Minuto; Gemma Battagliese; Maria Luisa Attilia; Eric R Braverman; Marina Romeo; Kenneth Blum; Mauro Ceccanti
Journal:  J Addict Res Ther       Date:  2016-04-26

8.  "Dopamine homeostasis" requires balanced polypharmacy: Issue with destructive, powerful dopamine agents to combat America's drug epidemic.

Authors:  Kenneth Blum; Edward J Modestino; Marjorie Gondré-Lewis; B William Downs; David Baron; Bruce Steinberg; David Siwicki; John Giordano; Thomas McLaughlin; Jennifer Neary; Mary Hauser; Lyle Fried; Rajendra D Badgaiyan
Journal:  J Syst Integr Neurosci       Date:  2017-11-17

9.  A Multi-Locus Approach to Treating Fibromyalgia by Boosting Dopaminergic Activity in the Meso-Limbic System of the Brain.

Authors:  Kenneth Blum; Marlene Oscar-Berman; Roger L Waite; Eric R Braverman; Florian Kreuk; Mona Li; Kristina Dushaj; Margaret A Madigan; Mary Hauser; Thomas Simpatico; Debmalya Barh
Journal:  J Genet Syndr Gene Ther       Date:  2014-01-27

10.  Stimulants for the Control of Hedonic Appetite.

Authors:  Alison S Poulton; Emily J Hibbert; Bernard L Champion; Ralph K H Nanan
Journal:  Front Pharmacol       Date:  2016-04-25       Impact factor: 5.810
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.