Literature DB >> 2407654

Effective vaccination of mice against leprosy bacilli with subunits of Mycobacterium leprae.

R H Gelber1, P J Brennan, S W Hunter, M W Munn, J M Monson, L P Murray, P Siu, M Tsang, E G Engleman, N Mohagheghpour.   

Abstract

Model vaccines against leprosy bacilli have consisted of nonvirulent, live, attenuated Mycobacterium bovis BCG and irradiated, heat-killed, or autoclaved intact M. leprae. We report that immunization with various cell wall fractions of M. leprae, progressively depleted of lipids, carbohydrates, and soluble proteins, as well as a partially purified protein(s) derived from a pellet fraction of sonicated M. leprae, conferred significant protection against subsequent infection with live leprosy bacilli. Moreover, lymphocytes from regional lymph nodes and spleens of mice immunized with these M. leprae-derived subunits responded by proliferation when stimulated with M. leprae in vitro. Our results provide the first evidence that vaccination with M. leprae-derived fractions protects mice against leprosy bacilli.

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Year:  1990        PMID： 2407654      PMCID： PMC258523          DOI： 10.1128/iai.58.3.711-718.1990

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  31 in total

1.  Suppression of antigen and mitogen induced human T lymphocyte DNA synthesis by bacterial lipopolysaccharide: mediation by monocyte activation and production of prostaglandins.

Authors:  J J Ellner; P J Spagnuolo
Journal:  J Immunol       Date:  1979-12       Impact factor: 5.422

2.  Elimination of Mycobacterium leprae subsequent to local in vivo activation of macrophages in lepromatous leprosy by other mycobacteria.

Authors:  J Convit; M E Pinardi; G Rodríguez Ochoa; M Ulrich; J L Avila; M Goihman
Journal:  Clin Exp Immunol       Date:  1974-06       Impact factor: 4.330

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Identification of an immunostimulating protein from Mycobacterium leprae.

Authors:  N Mohagheghpour; M W Munn; R H Gelber; E G Engleman
Journal:  Infect Immun       Date:  1990-03       Impact factor: 3.441

5.  Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions.

Authors:  C C Shepard; R Van Landingham; L L Walker
Journal:  Infect Immun       Date:  1976-10       Impact factor: 3.441

6.  Attempts to establish the armadillo (Dasypus novemcinctus Linn.) as a model for the study of leprosy. I. Report of lepromatoid leprosy in an experimentally infected armadillo.

Authors:  W F Kirchheimer; E E Storrs
Journal:  Int J Lepr Other Mycobact Dis       Date:  1971 Jul-Sep

7.  Induction of cell-mediated immunity to Mycobacterium leprae in guinea pigs.

Authors:  V Mehra; B R Bloom
Journal:  Infect Immun       Date:  1979-03       Impact factor: 3.441

8.  Neonatally thymectomized Lewis rats infected with Mycobacterium leprae: response to primary infection, secondary challenge, and large inocula.

Authors:  A H Fieldsteel; L Levy
Journal:  Infect Immun       Date:  1976-09       Impact factor: 3.441

9.  Induction of cell-mediated immunity to Mycobacterium leprae in mice.

Authors:  P J Patel; M J Lefford
Journal:  Infect Immun       Date:  1978-01       Impact factor: 3.441

10.  Factors influencing protection against experimental tuberculosis in mice by heat-stable cell wall vaccines.

Authors:  E Ribi; R L Anacker; W Brehmer; G Goode; C L Larson; R H List; K C Milner; W C Wicht
Journal:  J Bacteriol       Date:  1966-10       Impact factor: 3.490
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  17 in total

1.  Protective efficacy of different cell-wall fractions of Mycobacterium tuberculosis.

Authors:  I B Chugh; R Kansal; V K Vinayak; G K Khuller
Journal:  Folia Microbiol (Praha)       Date:  1992       Impact factor: 2.099

2.  Antigens of Brucella abortus S19 immunodominant for bovine lymphocytes as identified by one- and two-dimensional cellular immunoblotting.

Authors:  B M Brooks-Worrell; G A Splitter
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

3.  Identification of an immunostimulating protein from Mycobacterium leprae.

Authors:  N Mohagheghpour; M W Munn; R H Gelber; E G Engleman
Journal:  Infect Immun       Date:  1990-03       Impact factor: 3.441

Review 4.  Hansen's disease.

Authors:  R H Gelber
Journal:  West J Med       Date:  1993-06

Review 5.  Advances and hurdles on the way toward a leprosy vaccine.

Authors:  Malcolm S Duthie; Thomas P Gillis; Steven G Reed
Journal:  Hum Vaccin       Date:  2011-11-01

6.  Vaccination of mice with a soluble protein fraction of Mycobacterium leprae provides consistent and long-term protection against M. leprae infection.

Authors:  R H Gelber; L Murray; P Siu; M Tsang
Journal:  Infect Immun       Date:  1992-05       Impact factor: 3.441

Review 7.  Chemotherapy of lepromatous leprosy: recent developments and prospects for the future.

Authors:  R H Gelber
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-11       Impact factor: 3.267

8.  Vaccination with the ML0276 antigen reduces local inflammation but not bacterial burden during experimental Mycobacterium leprae infection.

Authors:  Vanitha S Raman; Joanne O'Donnell; H Remy Bailor; Wakako Goto; Ramanuj Lahiri; Thomas P Gillis; Steven G Reed; Malcolm S Duthie
Journal:  Infect Immun       Date:  2009-09-28       Impact factor: 3.441

9.  Isolation of Brucella abortus ssb and uvrA genes from a genomic library by use of lymphocytes as probes.

Authors:  Y Zhu; S C Oliveira; G A Splitter
Journal:  Infect Immun       Date:  1993-12       Impact factor: 3.441

10.  Vaccination with pure Mycobacterium leprae proteins inhibits M. leprae multiplication in mouse footpads.

Authors:  R H Gelber; V Mehra; B Bloom; L P Murray; P Siu; M Tsang; P J Brennan
Journal:  Infect Immun       Date:  1994-10       Impact factor: 3.441
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