Magnus Westin1, Krister Brantberg2. 1. Department of Audiology and Neurotology, Karolinska University Hospital, Stockholm, Sweden. 2. Department of Audiology and Neurotology, Karolinska University Hospital, Stockholm, Sweden. Electronic address: krister.brantberg@karolinska.se.
Abstract
OBJECTIVE: To explore the stimulus site and stimulus configuration dependency for bone-conducted low-frequency vibration-induced ocular vestibular evoked myogenic potentials (oVEMPs). METHODS: oVEMPs were tested in response to 125 Hz single cycle bone-conducted vibration in healthy subjects (n=12) and in patients with severe unilateral vestibular lesions (n=10). The stimulus sites were the mastoids and vertex. Both directions of initial stimulus motion were used. RESULTS: At mastoid stimulation, the oVEMP to initial laterally directed acceleration of the labyrinth was delayed approximately the length of time of a stimulus half-cycle, as compared with the response to initial medially directed acceleration. At vertex stimulation, the oVEMP to positive initial acceleration was similar to the oVEMP to mastoid stimulation causing lateral initial acceleration. Likewise, the oVEMP to vertex negative initial acceleration was similar to mastoid stimulation causing initial medial acceleration. Further, patients with unilateral vestibular loss had, compared to healthy subjects, similar oVEMP from the healthy labyrinth. CONCLUSIONS: A fundamental dependency on medially directed accelerations of the labyrinth, based on the latency differences revealed, may theoretically account for oVEMP in response to low-frequency stimulation. SIGNIFICANCE: Low-frequency bone vibration stimulation at vertex might serve for simultaneous oVEMP testing of both ears.
OBJECTIVE: To explore the stimulus site and stimulus configuration dependency for bone-conducted low-frequency vibration-induced ocular vestibular evoked myogenic potentials (oVEMPs). METHODS: oVEMPs were tested in response to 125 Hz single cycle bone-conducted vibration in healthy subjects (n=12) and in patients with severe unilateral vestibular lesions (n=10). The stimulus sites were the mastoids and vertex. Both directions of initial stimulus motion were used. RESULTS: At mastoid stimulation, the oVEMP to initial laterally directed acceleration of the labyrinth was delayed approximately the length of time of a stimulus half-cycle, as compared with the response to initial medially directed acceleration. At vertex stimulation, the oVEMP to positive initial acceleration was similar to the oVEMP to mastoid stimulation causing lateral initial acceleration. Likewise, the oVEMP to vertex negative initial acceleration was similar to mastoid stimulation causing initial medial acceleration. Further, patients with unilateral vestibular loss had, compared to healthy subjects, similar oVEMP from the healthy labyrinth. CONCLUSIONS: A fundamental dependency on medially directed accelerations of the labyrinth, based on the latency differences revealed, may theoretically account for oVEMP in response to low-frequency stimulation. SIGNIFICANCE: Low-frequency bone vibration stimulation at vertex might serve for simultaneous oVEMP testing of both ears.
Authors: Sendhil Govender; Sally M Rosengren; Danielle L Dennis; Louis J Z Lim; James G Colebatch Journal: Exp Brain Res Date: 2015-09-24 Impact factor: 1.972
Authors: James G Colebatch; Danielle L Dennis; Sendhil Govender; Peggy Chen; Neil P McAngus Todd Journal: Exp Brain Res Date: 2014-05-18 Impact factor: 1.972