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Literature DB >> 24076116

Hematopoietic defects and iPSC disease modeling: lessons learned.

Abstract

Hematopoiesis is a paradigm for stem cell biology in that it centers on differentiation of a self-renewing pluripotent precursor into multiple committed cell types with specific functions. The use of induced pluripotent stem cells (iPSCs) as a disease modeling tool has revealed numerous insights into the underlying pathophysiology of hematological diseases - those disorders arising from defective hematopoiesis. Likewise, studying hematopoiesis and the defects that can arise offer clues to understanding general stem cell survival and differentiation.

Entities: Chemical

Keywords: Bone marrow failure; Disease modeling; Induced pluripotent stem cells; Reprogramming

Mesh：

Substances：
Hemoglobins

Year: 2013 PMID： 24076116 PMCID： PMC3888024 DOI： 10.1016/j.imlet.2013.09.018

Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685

22 in total

1. Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins.

Authors: Teisha J Rowland; Alison J Blaschke; David E Buchholz; Sherry T Hikita; Lincoln V Johnson; Dennis O Clegg
Journal: J Tissue Eng Regen Med Date: 2012-04-18 Impact factor: 3.963

2. Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.

Authors: Keiki Kumano; Shunya Arai; Masataka Hosoi; Kazuki Taoka; Naoya Takayama; Makoto Otsu; Genta Nagae; Koki Ueda; Kumi Nakazaki; Yasuhiko Kamikubo; Koji Eto; Hiroyuki Aburatani; Hiromitsu Nakauchi; Mineo Kurokawa
Journal: Blood Date: 2012-05-16 Impact factor: 22.113

3. Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease.

Authors: Jizhong Zou; Prashant Mali; Xiaosong Huang; Sarah N Dowey; Linzhao Cheng
Journal: Blood Date: 2011-08-31 Impact factor: 22.113

Review 4. Generation of iPS cells from normal and malignant hematopoietic cells.

Authors: Keiki Kumano; Shunya Arai; Mineo Kurokawa
Journal: Int J Hematol Date: 2013-06-27 Impact factor: 2.490

5. In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1.

Authors: Paula Río; Néstor W Meza; Africa González-Murillo; Susana Navarro; Lara Alvarez; Jordi Surrallés; Maria Castella; Guillermo Guenechea; José C Segovia; Helmut Hanenberg; Juan A Bueren
Journal: Blood Date: 2008-09-23 Impact factor: 22.113

6. Lentiviral-mediated genetic correction of hematopoietic and mesenchymal progenitor cells from Fanconi anemia patients.

Authors: Ariana Jacome; Susana Navarro; Paula Río; Rosa M Yañez; Africa González-Murillo; M Luz Lozano; Maria Luisa Lamana; Julian Sevilla; Teresa Olive; Cristina Diaz-Heredia; Isabel Badell; Jesus Estella; Luis Madero; Guillermo Guenechea; José Casado; Jose C Segovia; Juan A Bueren
Journal: Mol Ther Date: 2009-03-10 Impact factor: 11.454

7. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.

Authors: Angel Raya; Ignasi Rodríguez-Pizà; Guillermo Guenechea; Rita Vassena; Susana Navarro; María José Barrero; Antonella Consiglio; Maria Castellà; Paula Río; Eduard Sleep; Federico González; Gustavo Tiscornia; Elena Garreta; Trond Aasen; Anna Veiga; Inder M Verma; Jordi Surrallés; Juan Bueren; Juan Carlos Izpisúa Belmonte
Journal: Nature Date: 2009-05-31 Impact factor: 49.962

8. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.

Authors: Lin Ye; Judy C Chang; Chin Lin; Xiaofang Sun; Jingwei Yu; Yuet Wai Kan
Journal: Proc Natl Acad Sci U S A Date: 2009-05-29 Impact factor: 11.205

9. Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.

Authors: Andrew J Finch; Christine Hilcenko; Nicolas Basse; Lesley F Drynan; Beatriz Goyenechea; Tobias F Menne; Africa González Fernández; Paul Simpson; Clive S D'Santos; Mark J Arends; Jean Donadieu; Christine Bellanné-Chantelot; Michael Costanzo; Charles Boone; Andrew N McKenzie; Stefan M V Freund; Alan J Warren
Journal: Genes Dev Date: 2011-05-01 Impact factor: 11.361

10. Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression.

Authors: Gabsang Lee; Christina N Ramirez; Hyesoo Kim; Nadja Zeltner; Becky Liu; Constantin Radu; Bhavneet Bhinder; Yong Jun Kim; In Young Choi; Bipasha Mukherjee-Clavin; Hakim Djaballah; Lorenz Studer
Journal: Nat Biotechnol Date: 2012-11-25 Impact factor: 54.908

2 in total

Review 1. DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist.

Authors: Leonidas Benetatos; George Vartholomatos; Eleftheria Hatzimichael
Journal: Cell Mol Life Sci Date: 2014-08-07 Impact factor: 9.261

Review 2. Advances in understanding and treating dystrophic epidermolysis bullosa.

Authors: Michael J Vanden Oever; Jakub Tolar
Journal: F1000Prime Rep Date: 2014-05-06

2 in total