Literature DB >> 25098353

DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist.

Leonidas Benetatos1, George Vartholomatos, Eleftheria Hatzimichael.   

Abstract

DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.

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Year:  2014        PMID： 25098353     DOI： 10.1007/s00018-014-1698-9

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  86 in total

1.  DLK1, delta-like 1 homolog (Drosophila), regulates tumor cell differentiation in vivo.

Authors:  Asma Begum; Yuri Kim; Qun Lin; Zhong Yun
Journal:  Cancer Lett       Date:  2011-12-03       Impact factor: 8.679

2.  DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma.

Authors:  Xiao Xu; Rui-Fang Liu; Xin Zhang; Li-Yu Huang; Fei Chen; Qian-Lan Fei; Ze-Guang Han
Journal:  Mol Cancer Ther       Date:  2012-01-11       Impact factor: 6.261

Review 3.  Hematopoiesis: a human perspective.

Authors:  Sergei Doulatov; Faiyaz Notta; Elisa Laurenti; John E Dick
Journal:  Cell Stem Cell       Date:  2012-02-03       Impact factor: 24.633

4.  Identification of defects in the transcriptional program during lineage-specific in vitro differentiation of CD34(+) cells selected from patients with both low- and high-risk myelodysplastic syndrome.

Authors:  Saskia Gueller; Martina Komor; Daniel Nowak; Claudia D Baldus; Sven de Vos; Dieter Hoelzer; Oliver G Ottmann; Wolf-K Hofmann
Journal:  Exp Hematol       Date:  2010-06-01       Impact factor: 3.084

Review 5.  Genetic and epigenetic variations in iPSCs: potential causes and implications for application.

Authors:  Gaoyang Liang; Yi Zhang
Journal:  Cell Stem Cell       Date:  2013-08-01       Impact factor: 24.633

Review 6.  Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma.

Authors:  Yunli Zhou; Xun Zhang; Anne Klibanski
Journal:  Mol Cell Endocrinol       Date:  2013-09-11       Impact factor: 4.102

7.  Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells.

Authors:  Matthias Stadtfeld; Effie Apostolou; Francesco Ferrari; Jiho Choi; Ryan M Walsh; Taiping Chen; Steen S K Ooi; Sang Yong Kim; Timothy H Bestor; Toshi Shioda; Peter J Park; Konrad Hochedlinger
Journal:  Nat Genet       Date:  2012-03-04       Impact factor: 38.330

8.  Preadipocytes proliferate and differentiate under the guidance of Delta-like 1 homolog (DLK1).

Authors:  Gunnhildur Asta Traustadottir; Rok Kosmina; Søren P Sheikh; Charlotte H Jensen; Ditte C Andersen
Journal:  Adipocyte       Date:  2013-05-13       Impact factor: 4.534

9.  The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas.

Authors:  Gabriela Schneider; Mark J Bowser; Dong-Myung Shin; Frederic G Barr; Mariusz Z Ratajczak
Journal:  Int J Oncol       Date:  2013-10-29       Impact factor: 5.650

10.  Newborns of obese parents have altered DNA methylation patterns at imprinted genes.

Authors:  A Soubry; S K Murphy; F Wang; Z Huang; A C Vidal; B F Fuemmeler; J Kurtzberg; A Murtha; R L Jirtle; J M Schildkraut; C Hoyo
Journal:  Int J Obes (Lond)       Date:  2013-10-25       Impact factor: 5.095
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  13 in total

1.  Lateral transfer of organophosphate degradation (opd) genes among soil bacteria: mode of transfer and contributions to organismal fitness.

Authors:  Dayananda Siddavattam; Harshita Yakkala; Devyani Samantarrai
Journal:  J Genet       Date:  2019-03       Impact factor: 1.166

Review 2.  Long non-coding RNAs and MYC association in hematological malignancies.

Authors:  Leonidas Benetatos; Agapi Benetatou; Georgios Vartholomatos
Journal:  Ann Hematol       Date:  2020-07-04       Impact factor: 3.673

3.  Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs.

Authors:  Dritan Liko; Andrzej Rzepiela; Vanja Vukojevic; Mihaela Zavolan; Michael N Hall
Journal:  Proc Natl Acad Sci U S A       Date:  2020-01-09       Impact factor: 11.205

Review 4.  Imprinted genes in myeloid lineage commitment in normal and malignant hematopoiesis.

Authors:  L Benetatos; G Vartholomatos
Journal:  Leukemia       Date:  2015-02-23       Impact factor: 11.528

5.  Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics.

Authors:  Athanasia D Panopoulos; Erin N Smith; Angelo D Arias; Peter J Shepard; Yuriko Hishida; Veronica Modesto; Kenneth E Diffenderfer; Clay Conner; William Biggs; Efren Sandoval; Agnieszka D'Antonio-Chronowska; W Travis Berggren; Juan Carlos Izpisua Belmonte; Kelly A Frazer
Journal:  Cell Stem Cell       Date:  2017-04-06       Impact factor: 24.633

6.  Neonatal Exposure to BPA, BDE-99, and PCB Produces Persistent Changes in Hepatic Transcriptome Associated With Gut Dysbiosis in Adult Mouse Livers.

Authors:  Joe Jongpyo Lim; Moumita Dutta; Joseph L Dempsey; Hans-Joachim Lehmler; James MacDonald; Theo Bammler; Cheryl Walker; Terrance J Kavanagh; Haiwei Gu; Sridhar Mani; Julia Yue Cui
Journal:  Toxicol Sci       Date:  2021-10-27       Impact factor: 4.109

7.  Expression level of miRNAs on chromosome 14q32.31 region correlates with tumor aggressiveness and survival of glioblastoma patients.

Authors:  Tal Shahar; Avital Granit; Daniel Zrihan; Tamar Canello; Hanna Charbit; Ofira Einstein; Uri Rozovski; Sharona Elgavish; Zvi Ram; Tali Siegal; Iris Lavon
Journal:  J Neurooncol       Date:  2016-08-29       Impact factor: 4.130

8.  Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

Authors:  Ivan Carcamo-Orive; Gabriel E Hoffman; Paige Cundiff; Noam D Beckmann; Sunita L D'Souza; Joshua W Knowles; Achchhe Patel; Dimitri Papatsenko; Fahim Abbasi; Gerald M Reaven; Sean Whalen; Philip Lee; Mohammad Shahbazi; Marc Y R Henrion; Kuixi Zhu; Sven Wang; Panos Roussos; Eric E Schadt; Gaurav Pandey; Rui Chang; Thomas Quertermous; Ihor Lemischka
Journal:  Cell Stem Cell       Date:  2016-12-22       Impact factor: 25.269

9.  Sex and age differences in the expression of liver microRNAs during the life span of F344 rats.

Authors:  Joshua C Kwekel; Vikrant Vijay; Tao Han; Carrie L Moland; Varsha G Desai; James C Fuscoe
Journal:  Biol Sex Differ       Date:  2017-02-03       Impact factor: 5.027

10.  A human haploid gene trap collection to study lncRNAs with unusual RNA biology.

Authors:  Aleksandra E Kornienko; Irena Vlatkovic; Jürgen Neesen; Denise P Barlow; Florian M Pauler
Journal:  RNA Biol       Date:  2016       Impact factor: 4.652
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