| Literature DB >> 24075572 |
Maria Conceição M Torres1, Roberta Jeane B Jorge, Rafael M Ximenes, Natacha Teresa Q Alves, João Victor de A Santos, Aline D Marinho, Helena S A Monteiro, Marcos H Toyama, Raimundo Braz-Filho, Edilberto R Silveira, Otília Deusdênia L Pessoa.
Abstract
From the leaves of Solanum campaniforme (Solanaceae), eight solanidane alkaloids were isolated, four of which contain a p-hydroxyphenylethylamine unit. Their structures were established as: 22β,23β-epoxy-solanida-1,4-dien-3-one; 22α,23α-epoxy-10-epi-solanida-1,4,9-trien-3-one; 22α,23α-epoxy-solanida-4-en-3-one; 22β,23β-epoxy-solanida-4-en-3-one; (E)-N-[8'(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4,9-trien-3-imine; (E)-N-[8'(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4-dien-3-imine; (Z)-N-[8'(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4,9-trien-3-imine and (Z)-N-[8'(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4-dien-3-imine. All structures were determined using spectroscopic techniques, such as 1D and 2D NMR, and HRESIMS. The cytotoxicity and the antiophidic activities of the alkaloids were evaluated. The alkaloids did not show any cytotoxicity, but inhibited the main toxic actions of Bothrops pauloensis venom.Entities:
Keywords: Bothrops pauloensis; Iminosolanidane alkaloids; Solanaceae; Solanidane alkaloids; Solanum campaniforme
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Year: 2013 PMID： 24075572 DOI： 10.1016/j.phytochem.2013.09.007
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072