| Literature DB >> 2407284 |
Abstract
The effect of pretreatment with mifepristone on prostaglandin-induced abortion was investigated in a double-blind randomized trial involving 100 women in the second trimester of pregnancy. The women were randomly allocated to receive either 600 mg oral mifepristone or placebo tablets 36 h before the administration of gemeprost pessaries. The median interval between administration of prostaglandin and abortion was significantly shorter in the mifepristone group (6.8 h) compared with the placebo group (15.8 h). The women pretreated with mifepristone required significantly fewer gemeprost pessaries to induce abortion and experienced significantly less pain than the women who had received placebo.Entities:
Keywords: Abortifacient Agents; Abortion, Drug Induced; Abortion, Induced; Biology; Comparative Studies; Endocrine System; Family Planning; Fertility Control, Postconception; Hormone Antagonists; Hormones; Physiology; Pregnancy; Pregnancy, Second Trimester; Prostaglandins; Prostaglandins, Synthetic--administraction and dosage; Reproduction; Research Methodology; Ru-486; Studies
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Year: 1990 PMID： 2407284 DOI： 10.1111/j.1471-0528.1990.tb01714.x
Source DB: PubMed Journal: Br J Obstet Gynaecol ISSN： 0306-5456