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Literature DB >> 24071843

Complex genetics of drug resistance in Mycobacterium tuberculosis.

Abstract

Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.

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Year: 2013 PMID： 24071843 DOI： 10.1038/ng.2769

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

14 in total

1. Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis.

Authors: Wanliang Shi; Xuelian Zhang; Xin Jiang; Haiming Yuan; Jong Seok Lee; Clifton E Barry; Honghai Wang; Wenhong Zhang; Ying Zhang
Journal: Science Date: 2011-08-11 Impact factor: 47.728

2. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.

Authors: Hongtai Zhang; Dongfang Li; Lili Zhao; Joy Fleming; Nan Lin; Ting Wang; Zhangyi Liu; Chuanyou Li; Nicholas Galwey; Jiaoyu Deng; Ying Zhou; Yuanfang Zhu; Yunrong Gao; Tong Wang; Shihua Wang; Yufen Huang; Ming Wang; Qiu Zhong; Lin Zhou; Tao Chen; Jie Zhou; Ruifu Yang; Guofeng Zhu; Haiying Hang; Jia Zhang; Fabin Li; Kanglin Wan; Jun Wang; Xian-En Zhang; Lijun Bi
Journal: Nat Genet Date: 2013-09-01 Impact factor: 38.330

Review 3. Advances in the development of new tuberculosis drugs and treatment regimens.

Authors: Alimuddin Zumla; Payam Nahid; Stewart T Cole
Journal: Nat Rev Drug Discov Date: 2013-05 Impact factor: 84.694

4. Mutations in extensively drug-resistant Mycobacterium tuberculosis that do not code for known drug-resistance mechanisms.

Authors: Alifiya S Motiwala; Yang Dai; Edward C Jones-López; Soo-Hee Hwang; Jong Seok Lee; Sang Nae Cho; Laura E Via; Clifton E Barry; David Alland
Journal: J Infect Dis Date: 2010-03-15 Impact factor: 5.226

5. Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.

Authors: Gang Sun; Tao Luo; Chongguang Yang; Xinran Dong; Jing Li; Yongqiang Zhu; Huajun Zheng; Weidong Tian; Shengyue Wang; Clifton E Barry; Jian Mei; Qian Gao
Journal: J Infect Dis Date: 2012-09-14 Impact factor: 5.226

6. In vitro combination studies of benzothiazinone lead compound BTZ043 against Mycobacterium tuberculosis.

Authors: Benoit Lechartier; Ruben C Hartkoorn; Stewart T Cole
Journal: Antimicrob Agents Chemother Date: 2012-08-27 Impact factor: 5.191

7. Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans.

Authors: Iñaki Comas; Mireia Coscolla; Tao Luo; Sonia Borrell; Kathryn E Holt; Midori Kato-Maeda; Julian Parkhill; Bijaya Malla; Stefan Berg; Guy Thwaites; Dorothy Yeboah-Manu; Graham Bothamley; Jian Mei; Lanhai Wei; Stephen Bentley; Simon R Harris; Stefan Niemann; Roland Diel; Abraham Aseffa; Qian Gao; Douglas Young; Sebastien Gagneux
Journal: Nat Genet Date: 2013-09-01 Impact factor: 38.330

8. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis.

Authors: Maha R Farhat; B Jesse Shapiro; Karen J Kieser; Razvan Sultana; Karen R Jacobson; Thomas C Victor; Robin M Warren; Elizabeth M Streicher; Alistair Calver; Alex Sloutsky; Devinder Kaur; Jamie E Posey; Bonnie Plikaytis; Marco R Oggioni; Jennifer L Gardy; James C Johnston; Mabel Rodrigues; Patrick K C Tang; Midori Kato-Maeda; Mark L Borowsky; Bhavana Muddukrishna; Barry N Kreiswirth; Natalia Kurepina; James Galagan; Sebastien Gagneux; Bruce Birren; Eric J Rubin; Eric S Lander; Pardis C Sabeti; Megan Murray
Journal: Nat Genet Date: 2013-09-01 Impact factor: 38.330

9. Whole-genome sequencing for rapid susceptibility testing of M. tuberculosis.

Authors: Claudio U Köser; Josephine M Bryant; Jennifer Becq; M Estée Török; Matthew J Ellington; Marc A Marti-Renom; Andrew J Carmichael; Julian Parkhill; Geoffrey P Smith; Sharon J Peacock
Journal: N Engl J Med Date: 2013-07-18 Impact factor: 91.245

10. The role of selection in shaping diversity of natural M. tuberculosis populations.

Authors: Caitlin S Pepperell; Amanda M Casto; Andrew Kitchen; Julie M Granka; Omar E Cornejo; Edward C Holmes; Eddie C Holmes; Bruce Birren; James Galagan; Marcus W Feldman
Journal: PLoS Pathog Date: 2013-08-15 Impact factor: 6.823

12 in total

1. 1,4-azaindole, a potential drug candidate for treatment of tuberculosis.

Authors: Monalisa Chatterji; Radha Shandil; M R Manjunatha; Suresh Solapure; Vasanthi Ramachandran; Naveen Kumar; Ramanatha Saralaya; Vijender Panduga; Jitendar Reddy; K R Prabhakar; Sreevalli Sharma; Claire Sadler; Christopher B Cooper; Khisi Mdluli; Pravin S Iyer; Shridhar Narayanan; Pravin S Shirude
Journal: Antimicrob Agents Chemother Date: 2014-06-23 Impact factor: 5.191

10. Molecular epidemiology and clinical characteristics of drug-resistant Mycobacterium tuberculosis in a tuberculosis referral hospital in China.

Authors: Qi Wang; Susanna K P Lau; Fei Liu; Yanlin Zhao; Hong Min Li; Bing Xi Li; Yong Liang Hu; Patrick C Y Woo; Cui Hua Liu
Journal: PLoS One Date: 2014-10-10 Impact factor: 3.240

Complex genetics of drug resistance in Mycobacterium tuberculosis.

1. Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis.

2. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.

Review 3. Advances in the development of new tuberculosis drugs and treatment regimens.

4. Mutations in extensively drug-resistant Mycobacterium tuberculosis that do not code for known drug-resistance mechanisms.

5. Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.

6. In vitro combination studies of benzothiazinone lead compound BTZ043 against Mycobacterium tuberculosis.

7. Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans.

8. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis.

9. Whole-genome sequencing for rapid susceptibility testing of M. tuberculosis.

10. The role of selection in shaping diversity of natural M. tuberculosis populations.

1. 1,4-azaindole, a potential drug candidate for treatment of tuberculosis.

2. NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy.

3. Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates.

Review 4. Translating genomics research into control of tuberculosis: lessons learned and future prospects.

5. KvarQ: targeted and direct variant calling from fastq reads of bacterial genomes.

6. The road to drug resistance in Mycobacterium tuberculosis.

7. MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.

Review 8. Insights into battles between Mycobacterium tuberculosis and macrophages.

Review 9. Whole-genome sequencing to control antimicrobial resistance.

10. Molecular epidemiology and clinical characteristics of drug-resistant Mycobacterium tuberculosis in a tuberculosis referral hospital in China.