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Literature DB >> 24071842

Genomics informs glioblastoma biology.

David L Schonberg¹, Shideng Bao, Jeremy N Rich.

Abstract

Identifying genomic alterations in cancer does not guarantee therapeutic benefit. A new study combining DNA and RNA sequencing with functional validation uncovers new genetic driver alterations in glioblastoma with potential for clinical translation.

Entities: Disease

Mesh：

Year: 2013 PMID： 24071842 DOI： 10.1038/ng.2775

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

14 in total

1. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

Authors: Olga A Guryanova; Qiulian Wu; Lin Cheng; Justin D Lathia; Zhi Huang; Jinbo Yang; Jennifer MacSwords; Christine E Eyler; Roger E McLendon; John M Heddleston; Weinian Shou; Dolores Hambardzumyan; Jeongwu Lee; Anita B Hjelmeland; Andrew E Sloan; Markus Bredel; George R Stark; Jeremy N Rich; Shideng Bao
Journal: Cancer Cell Date: 2011-04-12 Impact factor: 31.743

2. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma.

Authors: Brittany C Parker; Matti J Annala; David E Cogdell; Kirsi J Granberg; Yan Sun; Ping Ji; Xia Li; Joy Gumin; Hong Zheng; Limei Hu; Olli Yli-Harja; Hannu Haapasalo; Tapio Visakorpi; Xiuping Liu; Chang-Gong Liu; Raymond Sawaya; Gregory N Fuller; Kexin Chen; Frederick F Lang; Matti Nykter; Wei Zhang
Journal: J Clin Invest Date: 2013-01-09 Impact factor: 14.808

Review 3. Emerging insights into the molecular and cellular basis of glioblastoma.

Authors: Gavin P Dunn; Mikael L Rinne; Jill Wykosky; Giannicola Genovese; Steven N Quayle; Ian F Dunn; Pankaj K Agarwalla; Milan G Chheda; Benito Campos; Alan Wang; Cameron Brennan; Keith L Ligon; Frank Furnari; Webster K Cavenee; Ronald A Depinho; Lynda Chin; William C Hahn
Journal: Genes Dev Date: 2012-04-15 Impact factor: 11.361

4. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival.

Authors: Siyuan Zheng; Jun Fu; Rahulsimham Vegesna; Yong Mao; Lindsey E Heathcock; Wandaliz Torres-Garcia; Ravesanker Ezhilarasan; Shuzhen Wang; Aaron McKenna; Lynda Chin; Cameron W Brennan; W K Alfred Yung; John N Weinstein; Kenneth D Aldape; Erik P Sulman; Ken Chen; Dimpy Koul; Roel G W Verhaak
Journal: Genes Dev Date: 2013-06-24 Impact factor: 11.361

5. Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction.

Authors: Inbal Israely; Rui M Costa; Cui Wei Xie; Alcino J Silva; Kenneth S Kosik; Xin Liu
Journal: Curr Biol Date: 2004-09-21 Impact factor: 10.834

6. Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development.

Authors: Jyothi Arikkath; I-Feng Peng; Yu Gie Ng; Inbal Israely; Xin Liu; Erik M Ullian; Louis F Reichardt
Journal: J Neurosci Date: 2009-04-29 Impact factor: 6.167

7. Transforming fusions of FGFR and TACC genes in human glioblastoma.

Authors: Devendra Singh; Joseph Minhow Chan; Pietro Zoppoli; Francesco Niola; Ryan Sullivan; Angelica Castano; Eric Minwei Liu; Jonathan Reichel; Paola Porrati; Serena Pellegatta; Kunlong Qiu; Zhibo Gao; Michele Ceccarelli; Riccardo Riccardi; Daniel J Brat; Abhijit Guha; Ken Aldape; John G Golfinos; David Zagzag; Tom Mikkelsen; Gaetano Finocchiaro; Anna Lasorella; Raul Rabadan; Antonio Iavarone
Journal: Science Date: 2012-07-26 Impact factor: 47.728

8. Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

Authors: Andrey Korshunov; Jochen Meyer; David Capper; Arne Christians; Marc Remke; Hendrik Witt; Stefan Pfister; Andreas von Deimling; Christian Hartmann
Journal: Acta Neuropathol Date: 2009-06-19 Impact factor: 17.088

9. Expression of delta-catenin is associated with progression of human astrocytoma.

Authors: MingHao Wang; Qianze Dong; Di Zhang; YunJie Wang
Journal: BMC Cancer Date: 2011-12-12 Impact factor: 4.430

10. The integrated landscape of driver genomic alterations in glioblastoma.

Authors: Veronique Frattini; Vladimir Trifonov; Joseph Minhow Chan; Angelica Castano; Marie Lia; Francesco Abate; Stephen T Keir; Alan X Ji; Pietro Zoppoli; Francesco Niola; Carla Danussi; Igor Dolgalev; Paola Porrati; Serena Pellegatta; Adriana Heguy; Gaurav Gupta; David J Pisapia; Peter Canoll; Jeffrey N Bruce; Roger E McLendon; Hai Yan; Ken Aldape; Gaetano Finocchiaro; Tom Mikkelsen; Gilbert G Privé; Darell D Bigner; Anna Lasorella; Raul Rabadan; Antonio Iavarone
Journal: Nat Genet Date: 2013-08-05 Impact factor: 38.330

10 in total

Genomics informs glioblastoma biology.

1. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

2. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma.

Review 3. Emerging insights into the molecular and cellular basis of glioblastoma.

4. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival.

5. Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction.

6. Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development.

7. Transforming fusions of FGFR and TACC genes in human glioblastoma.

8. Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

9. Expression of delta-catenin is associated with progression of human astrocytoma.

10. The integrated landscape of driver genomic alterations in glioblastoma.

1. Androgen receptor signaling regulates growth of glioblastoma multiforme in men.

2. MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.

3. Growth of glioblastoma is inhibited by miR-133-mediated EGFR suppression.

4. Comprehensive analysis of microRNA expression profile in malignant glioma tissues.

5. Inhibition of FoxO1 nuclear exclusion prevents metastasis of glioblastoma.

6. EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2.

Review 7. The persistent contributions of RNA to eukaryotic gen(om)e architecture and cellular function.

8. Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations.

9. Rewiring of purine metabolism in response to acidosis stress in glioma stem cells.

10. Interplay of VEGFa and MMP2 regulates invasion of glioblastoma.