Literature DB >> 24070652

Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.

Xiaobo Hu1, Hui Wei, Laiman Xiang, Oleg Chertov, Alan S Wayne, Tapan K Bera, Ira Pastan.   

Abstract

Moxetumomab pasudotox (HA22) is an immunotoxin with an anti-CD22 Fv fused to a portion of Pseudomonas exotoxin A that kills CD22 expressing ALL cells. HA22 produced significant responses in some cases of ALL. To understand how to increase response rate, we isolated HA22-resistant KOPN-8 cells and found that HA22 cannot inactivate elongation factor-2 (EF2) due to low levels of DPH1 RNA and protein. Resistance was associated with methylation of the CpG island in the DPH1 promoter. 5-Azacytidine prevented resistance and methylation of the CpG residues and merits evaluation to determine if it can increase the efficacy of HA22 in ALL. Published by Elsevier Ltd.

Entities:  

Keywords:  ADP-ribosylation; DNA methylation; Diphthamide synthesis; Drug resistance; Epigenetic regulation

Mesh：

Substances：

Year:  2013        PMID： 24070652      PMCID： PMC3818433          DOI： 10.1016/j.leukres.2013.08.005

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  39 in total

1.  Recombinant immunotoxins in the treatment of cancer.

Authors:  Ira Pastan; Richard Beers; Tapan K Bera
Journal:  Methods Mol Biol       Date:  2004

2.  Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.

Authors:  S Fulda; M U Küfer; E Meyer; F van Valen; B Dockhorn-Dworniczak; K M Debatin
Journal:  Oncogene       Date:  2001-09-13       Impact factor: 9.867

3.  Establishment of a novel heterotransplantable acute lymphoblastic leukemia cell line with a t(17;19) chromosomal translocation the growth of which is inhibited by interleukin-3.

Authors:  K Ohyashiki; H Fujieda; J Miyauchi; J H Ohyashiki; T Tauchi; M Saito; S Nakazawa; K Abe; K Yamamoto; S C Clark
Journal:  Leukemia       Date:  1991-04       Impact factor: 11.528

Review 4.  DNA methylation: an epigenetic pathway to cancer and a promising target for anticancer therapy.

Authors:  Jesper Worm; Per Guldberg
Journal:  J Oral Pathol Med       Date:  2002-09       Impact factor: 4.253

5.  In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin.

Authors:  T J Moehring; D E Danley; J M Moehring
Journal:  Mol Cell Biol       Date:  1984-04       Impact factor: 4.272

Review 6.  Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.

Authors:  H G Drexler; H Quentmeier; R A F MacLeod
Journal:  Leukemia       Date:  2004-02       Impact factor: 11.528

7.  A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin.

Authors:  V K Chaudhary; C Queen; R P Junghans; T A Waldmann; D J FitzGerald; I Pastan
Journal:  Nature       Date:  1989-06-01       Impact factor: 49.962

8.  DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae.

Authors:  L C Mattheakis; W H Shen; R J Collier
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

9.  Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae.

Authors:  J Y Chen; J W Bodley; D M Livingston
Journal:  Mol Cell Biol       Date:  1985-12       Impact factor: 4.272

10.  Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol.

Authors:  M Ogata; V K Chaudhary; I Pastan; D J FitzGerald
Journal:  J Biol Chem       Date:  1990-11-25       Impact factor: 5.486
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  9 in total

1.  5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox.

Authors:  Fabian Müller; Tyler Cunningham; Stephanie Stookey; Chin-Hsien Tai; Sandra Burkett; Parthav Jailwala; Maryalice Stetler Stevenson; Margaret C Cam; Alan S Wayne; Ira Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-05       Impact factor: 11.205

2.  DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance.

Authors:  Katsuhiro Togami; Timothy Pastika; Jason Stephansky; Mahmoud Ghandi; Amanda L Christie; Kristen L Jones; Carl A Johnson; Ross W Lindsay; Christopher L Brooks; Anthony Letai; Jeffrey W Craig; Olga Pozdnyakova; David M Weinstock; Joan Montero; Jon C Aster; Cory M Johannessen; Andrew A Lane
Journal:  J Clin Invest       Date:  2019-11-01       Impact factor: 14.808

Review 3.  Immunotoxins for leukemia.

Authors:  Alan S Wayne; David J Fitzgerald; Robert J Kreitman; Ira Pastan
Journal:  Blood       Date:  2014-02-27       Impact factor: 22.113

4.  Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.

Authors:  Sebastian Stahl; Ana Rita da Silva Mateus Seidl; Axel Ducret; Sabine Kux van Geijtenbeek; Sven Michel; Tomas Racek; Fabian Birzele; Alexander K Haas; Ruediger Rueger; Michael Gerg; Gerhard Niederfellner; Ira Pastan; Ulrich Brinkmann
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-10       Impact factor: 11.205

5.  Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.

Authors:  Alan S Wayne; Nirali N Shah; Deepa Bhojwani; Lewis B Silverman; James A Whitlock; Maryalice Stetler-Stevenson; Weili Sun; Meina Liang; Jie Yang; Robert J Kreitman; Mark C Lanasa; Ira Pastan
Journal:  Blood       Date:  2017-08-09       Impact factor: 22.113

6.  Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2.

Authors:  Rita Mateus-Seidl; Sebastian Stahl; Stefan Dengl; Fabian Birzele; Hedda Herrmuth; Klaus Mayer; Gerhard Niederfellner; Xiu-Fen Liu; Ira Pastan; Ulrich Brinkmann
Journal:  Biol Chem       Date:  2019-03-26       Impact factor: 4.700

7.  Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line.

Authors:  Kevin Hollevoet; Emily Mason-Osann; Fabian Müller; Ira Pastan
Journal:  PLoS One       Date:  2015-03-24       Impact factor: 3.752

8.  Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADPRibosylating Toxins.

Authors:  Klaus Mayer; Anna Schröder; Jerome Schnitger; Sebastian Stahl; Ulrich Brinkmann
Journal:  Toxins (Basel)       Date:  2017-02-24       Impact factor: 5.075

Review 9.  Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy.

Authors:  Michael Dieffenbach; Ira Pastan
Journal:  Biomolecules       Date:  2020-06-30
  9 in total

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