Literature DB >> 24067347

Aldehyde dehydrogenase 2 as a potential protective factor for renal insufficiency in Japanese subjects with heart failure: a pilot study.

K Morita1, K Oniki1, H Miyazaki1, J Saruwatari1, Y Ogata2, M Mizobe3, M Yamamuro3, S Hokimoto3, H Ogawa3, K Nakagawa4.   

Abstract

The association between the aldehyde dehydrogenase 2 (ALDH2, rs671) genotypes and the estimated glomerular filtration rate (eGFR) was investigated in Japanese hypertensive patients with/without coronary artery disease or with ischemic heart failure (HF), and age/sex-matched normotensive healthy controls. The eGFRs were significantly lower in the HF subjects with the ALDH2 *2/*2 genotype than in those with the other genotypes. Multiple regression analyses adjusted by the potentially confounding factors showed the *2/*2 genotype to be significantly associated with the decreased eGFR, compared to the *1/*1 genotype (β = 31.99 ml min1 per 1.73 m2, P < 0.01).

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Year:  2013        PMID： 24067347     DOI： 10.1038/jhh.2013.90

Source DB:  PubMed          Journal:  J Hum Hypertens        ISSN： 0950-9240            Impact factor:   3.012


  12 in total

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Review 2.  Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.

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6.  The combination of mitochondrial low enzyme-activity aldehyde dehydrogenase 2 allele and superoxide dismutase 2 genotypes increases the risk of hypertension in relation to alcohol consumption.

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Journal:  Eur Heart J       Date:  2009-12-25       Impact factor: 29.983
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