Literature DB >> 240658

Metabolism of tolmetin in rat, monkey, and man.

D D Sumner, P G Dayton, S A Cucinell, J Plostnieks.   

Abstract

5-p-Carboxybenzoyl-1-methylpyrrole-2-acetic acid has been identified in the rat, monkey, and man as the major urinary metabolite of tolmetin, a new nonsteroidal anti-inflammatory agent. Conjugation of tolmetin, a major mode of disposition in man and monkey, was not observed in the rat.

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Year:  1975        PMID: 240658

Source DB:  PubMed          Journal:  Drug Metab Dispos        ISSN: 0090-9556            Impact factor:   3.922


  8 in total

Review 1.  Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1978-06       Impact factor: 9.546

2.  Pharmacokinetics and metabolism of tolmetin in normal and adjuvant arthritic Lewis rats.

Authors:  J M Grindel; B H Migdalof; K A Yorgey; J F Pritchard
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1982 Oct-Dec       Impact factor: 2.441

3.  Pharmacokinetics of tolmetin with and without concomitant administration of antacid in man.

Authors:  J W Ayres; D J Weidler; J MacKichan; E Sakmar; M R Hallmark; E F Lemanowicz; J G Wagner
Journal:  Eur J Clin Pharmacol       Date:  1977-12-28       Impact factor: 2.953

4.  In vitro metabolism of the analgesic agent, RWJ-37874, in rat and human.

Authors:  W N Wu; L A McKown; J R Carson
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2003 Apr-Jun       Impact factor: 2.441

5.  Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma.

Authors:  J C Ojingwa; H Spahn-Langguth; L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1994-02

6.  Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro.

Authors:  A Munafo; A F McDonagh; P C Smith; L Z Benet
Journal:  Pharm Res       Date:  1990-01       Impact factor: 4.200

Review 7.  Clinical pharmacokinetics of non-steroidal anti-inflammatory drugs.

Authors:  R K Verbeeck; J L Blackburn; G R Loewen
Journal:  Clin Pharmacokinet       Date:  1983 Jul-Aug       Impact factor: 6.447

Review 8.  Metabolic-Hydroxy and Carboxy Functionalization of Alkyl Moieties in Drug Molecules: Prediction of Structure Influence and Pharmacologic Activity.

Authors:  Babiker M El-Haj; Samrein B M Ahmed
Journal:  Molecules       Date:  2020-04-22       Impact factor: 4.411

  8 in total

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