| Literature DB >> 24060877 |
Sirwan Muhammed Ameen1, Michel Drancourt.
Abstract
Five type strains and 55 Mycobacterium tuberculosis complex clinical isolates were found resistant to trimethoprim with a MIC of >200 mg/liter and susceptible to both sulfadiazine and cotrimoxazole with a MIC90 of 10 mg/liter. Two M. canettii isolates uniquely yielded silent mutations C156 → T and G238 → C in the folP1 gene. Combined with scarce published data, these data indicate that sulfamides could be considered alternative antituberculous antibiotics.Entities:
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Year: 2013 PMID: 24060877 PMCID: PMC3837923 DOI: 10.1128/AAC.01683-13
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191