Literature DB >> 21709103

Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex.

Michaela Projahn1, Claudio U Köser, Susanne Homolka, David K Summers, John A C Archer, Stefan Niemann.   

Abstract

Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.

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Year:  2011        PMID: 21709103      PMCID: PMC3165319          DOI: 10.1128/AAC.00555-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  37 in total

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Review 3.  TB database 2010: overview and update.

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Journal:  Tuberculosis (Edinb)       Date:  2010-05-20       Impact factor: 3.131

4.  Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.

Authors:  Feng Wang; Paras Jain; Gulcin Gulten; Zhen Liu; Yicheng Feng; Krishna Ganesula; Alifiya S Motiwala; Thomas R Ioerger; David Alland; Catherine Vilchèze; William R Jacobs; James C Sacchettini
Journal:  Antimicrob Agents Chemother       Date:  2010-06-21       Impact factor: 5.191

5.  Rapid molecular detection of tuberculosis and rifampin resistance.

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Journal:  N Engl J Med       Date:  2010-09-01       Impact factor: 91.245

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Authors:  Thomas Weniger; Justina Krawczyk; Philip Supply; Stefan Niemann; Dag Harmsen
Journal:  Nucleic Acids Res       Date:  2010-05-10       Impact factor: 16.971

7.  Single-nucleotide polymorphisms in Rv2629 are specific for Mycobacterium tuberculosis genotypes Beijing and Ghana but not associated with rifampin resistance.

Authors:  Susanne Homolka; Claudio Köser; John Archer; Sabine Rüsch-Gerdes; Stefan Niemann
Journal:  J Clin Microbiol       Date:  2008-11-19       Impact factor: 5.948

8.  Origin, spread and demography of the Mycobacterium tuberculosis complex.

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9.  Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints.

Authors:  Stefan Niemann; Claudio U Köser; Sebastien Gagneux; Claudia Plinke; Susanne Homolka; Helen Bignell; Richard J Carter; R Keira Cheetham; Anthony Cox; Niall A Gormley; Paula Kokko-Gonzales; Lisa J Murray; Roberto Rigatti; Vincent P Smith; Felix P M Arends; Helen S Cox; Geoff Smith; John A C Archer
Journal:  PLoS One       Date:  2009-10-12       Impact factor: 3.240

10.  Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies.

Authors:  Iñaki Comas; Susanne Homolka; Stefan Niemann; Sebastien Gagneux
Journal:  PLoS One       Date:  2009-11-12       Impact factor: 3.240

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  6 in total

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2.  In vitro susceptibility of Mycobacterium tuberculosis to trimethoprim and sulfonamides in France.

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Journal:  Antimicrob Agents Chemother       Date:  2013-09-23       Impact factor: 5.191

Review 3.  Importance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistance.

Authors:  Claudio U Köser; Silke Feuerriegel; David K Summers; John A C Archer; Stefan Niemann
Journal:  Antimicrob Agents Chemother       Date:  2012-09-24       Impact factor: 5.191

4.  Genotypic Analysis of Genes Associated with Independent Resistance and Cross-Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis Clinical Isolates.

Authors:  Johana Rueda; Teresa Realpe; Gloria Isabel Mejia; Elsa Zapata; Juan Carlos Rozo; Beatriz Eugenia Ferro; Jaime Robledo
Journal:  Antimicrob Agents Chemother       Date:  2015-09-14       Impact factor: 5.191

5.  Molecular Characterization of Prothionamide-Resistant Mycobacterium tuberculosis Isolates in Southern China.

Authors:  Yaoju Tan; Biyi Su; Huiwen Zheng; Yuanyuan Song; Yufeng Wang; Yu Pang
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6.  Genetic signatures of Mycobacterium tuberculosis Nonthaburi genotype revealed by whole genome analysis of isolates from tuberculous meningitis patients in Thailand.

Authors:  Olabisi Oluwabukola Coker; Angkana Chaiprasert; Chumpol Ngamphiw; Sissades Tongsima; Sanjib Mani Regmi; Taane G Clark; Rick Twee Hee Ong; Yik-Ying Teo; Therdsak Prammananan; Prasit Palittapongarnpim
Journal:  PeerJ       Date:  2016-04-12       Impact factor: 2.984

  6 in total

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