Literature DB >> 2405860

Growth-inhibitory effects of 1,25-dihydroxyvitamin D3 on normal human keratinocytes cultured in serum-free medium.

K Matsumoto1, K Hashimoto, Y Nishida, M Hashiro, K Yoshikawa.   

Abstract

The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the growth of normal human keratinocytes cultured in serum-free medium was investigated. 1,25(OH)2D3 inhibited the cell growth at 10(-7) M by 75.3% and at 10(-6) M almost completely. The growth inhibition was accompanied by changes related to proliferation: (1) remarkable inhibition of DNA synthesis, (2) the decrease in the number of high-affinity receptors for epidermal growth factor, with almost no change in total receptor number, (3) the rapid decrease in c-myc mRNA level. The inhibition of DNA synthesis and the decrease of c-myc mRNA expression occurred at 3 h after the addition of 1,25(OH)2D3. These results suggest that decrease of c-myc mRNA expression is one of the primary effects of 1,25(OH)2D3 in the growth inhibition of human keratinocytes.

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Year:  1990        PMID： 2405860     DOI： 10.1016/0006-291x(90)90898-w

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

1.  Inhibitory effect of 1 alpha,25-dihydroxyvitamin D3 on mast cell proliferation and A23187-induced histamine release, also accompanied by a decreased c-kit receptor.

Authors:  N Toyota; H Sakai; H Takahashi; Y Hashimoto; H Iizuka
Journal:  Arch Dermatol Res       Date:  1996-10       Impact factor: 3.017

2.  The mRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes.

Authors:  N M Hanafin; K S Persons; M F Holick
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-03       Impact factor: 2.416

Review 3.  Vitamin D metabolism and function in the skin.

Authors:  Daniel D Bikle
Journal:  Mol Cell Endocrinol       Date:  2011-06-01       Impact factor: 4.102

4.  Hypertrophic Scars: Are Vitamins and Inflammatory Biomarkers Related with the Pathophysiology of Wound Healing?

Authors:  Inês Correia-Sá; Paula Serrão; Marisa Marques; Maria A Vieira-Coelho
Journal:  Obes Surg       Date:  2017-12       Impact factor: 4.129

5.  Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.

Authors:  Saskia Lippens; Mark Kockx; Geertrui Denecker; Michiel Knaapen; An Verheyen; Ruben Christiaen; Erwin Tschachler; Peter Vandenabeele; Wim Declercq
Journal:  Am J Pathol       Date:  2004-09       Impact factor: 4.307

6.  EGF receptor expression and growth of psoriatic and normal human keratinocytes are modulated by 1.25 (OH)2-vitamin D3 ex vivo.

Authors:  A M Boisseau-Garsaud; P Donatien; C Margerin; A Taïeb
Journal:  Arch Dermatol Res       Date:  1996-07       Impact factor: 3.017

7.  1,25(OH)2D3 regulates c-myc mRNA levels in tonsillar T lymphocytes.

Authors:  R Karmali; M Hewison; N Rayment; S M Farrow; A Brennan; D R Katz; J L O'Riordan
Journal:  Immunology       Date:  1991-12       Impact factor: 7.397

Review 8.  Vitamin D3 and skin diseases.

Authors:  K Kragballe
Journal:  Arch Dermatol Res       Date:  1992       Impact factor: 3.017

9.  Antiproliferative effects of the biologically active metabolite of vitamin D3 (1,25 [OH]2 D3) on head and neck squamous cell carcinoma cell lines.

Authors:  J Kornfehl; M Formanek; A Temmel; B Knerer; M Willheim
Journal:  Eur Arch Otorhinolaryngol       Date:  1996       Impact factor: 2.503

Review 10.  Vitamin D and human health: lessons from vitamin D receptor null mice.

Authors:  Roger Bouillon; Geert Carmeliet; Lieve Verlinden; Evelyne van Etten; Annemieke Verstuyf; Hilary F Luderer; Liesbet Lieben; Chantal Mathieu; Marie Demay
Journal:  Endocr Rev       Date:  2008-08-11       Impact factor: 19.871
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