Literature DB >> 24054539

A parallel increase in placental oxidative stress and antioxidant defenses occurs in pre-gestational type 1 but not gestational diabetes.

J R Araújo1, C Ramalho, A Correia-Branco, A Faria, T Ferraz, E Keating, F Martel.   

Abstract

We aimed to determine the oxidative stress status in placentas obtained from gestational (GDM) and type 1 (T1D) diabetic pregnancies. Malonaldehyde and protein carbonyls, two biomarkers of oxidative damage, were higher in T1D but not in GDM placentas. Also, higher reduced glutathione and lower oxidized glutathione levels and higher glutathione peroxidase activity were found in T1D but not in GDM placentas. These results suggest that T1D placentas may develop a protective antioxidant mechanism to overcome higher oxidative stress levels.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GDM; GSX; MDA; Maternal diabetes; Oxidative stress; Placenta; T1D; gestational diabetic pregnancies; malonaldehyde; pre-gestational type 1 diabetic pregnancies; tert-BOOH; tert-butyl hydroperoxide; total glutathione

Mesh：

Substances：

Year:  2013        PMID： 24054539     DOI： 10.1016/j.placenta.2013.09.001

Source DB:  PubMed          Journal:  Placenta        ISSN： 0143-4004            Impact factor:   3.481


  6 in total

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3.  Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants.

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Journal:  Int J Mol Sci       Date:  2018-10-17       Impact factor: 5.923
  6 in total

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