Chao Liu1, Zhen-gang Xu. 1. Department of Head and Neck Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Abstract
OBJECTIVE: To discuss the clinical relevant factors causing recurrence and failure of laryngeal cancer after partial laryngectomy. METHODS: The clinical data of 183 patients with laryngeal cancer who underwent partial laryngectomy from January 2005 to July 2009 in our hospital were analyzed retrospectively. 12 selected factors which might cause recurrence including sex, age, smoking condition, drinking condition, laryngeal cancer type, T stage, N stage, clinical stage, pathological grade, mode of operation, radiotherapy and margin status were analyzed. RESULTS: In the 183 patients, 37 cases were recurrence, the recurrence rate was 20.2%, 3-year survival rate was 83.1%, and 5-year-expected survival rate was 71.8%. Seven factors, i.e. T stage, N stage, pathological grades, surgical margins, radiotherapy, drinking and smoking condition were associated with recurrence after partial laryngectomy. Multivariate analysis showed that drinking condition, surgical margins, adjuvant radiotherapy and pN stage were the main factors affecting the prognosis of patients with partial laryngectomy, and they all were risk factors. CONCLUSIONS: Simple surgical treatment of early laryngeal cancer alone can achieve satisfactory therapeutic effect. However, multidisciplinary treatment mode of the operation combined with radiotherapy should be considered for patients with advanced laryngeal carcinoma and positive surgical margins.
OBJECTIVE: To discuss the clinical relevant factors causing recurrence and failure of laryngeal cancer after partial laryngectomy. METHODS: The clinical data of 183 patients with laryngeal cancer who underwent partial laryngectomy from January 2005 to July 2009 in our hospital were analyzed retrospectively. 12 selected factors which might cause recurrence including sex, age, smoking condition, drinking condition, laryngeal cancer type, T stage, N stage, clinical stage, pathological grade, mode of operation, radiotherapy and margin status were analyzed. RESULTS: In the 183 patients, 37 cases were recurrence, the recurrence rate was 20.2%, 3-year survival rate was 83.1%, and 5-year-expected survival rate was 71.8%. Seven factors, i.e. T stage, N stage, pathological grades, surgical margins, radiotherapy, drinking and smoking condition were associated with recurrence after partial laryngectomy. Multivariate analysis showed that drinking condition, surgical margins, adjuvant radiotherapy and pN stage were the main factors affecting the prognosis of patients with partial laryngectomy, and they all were risk factors. CONCLUSIONS: Simple surgical treatment of early laryngeal cancer alone can achieve satisfactory therapeutic effect. However, multidisciplinary treatment mode of the operation combined with radiotherapy should be considered for patients with advanced laryngeal carcinoma and positive surgical margins.