OBJECTIVE: To describe a protocol for transperineal sector biopsies (TPSB) of the prostate and present the clinical experience of this technique in a UK population. PATIENTS AND METHODS: A retrospective review of a single-centre experience of TPSB approach was undertaken that preferentially, but not exclusively, targeted the peripheral zone of the prostate with 24-38 cores using a 'sector plan'. Procedures were carried out under general anaesthetic in most patients. Between January 2007 and August 2011, 634 consecutive patients underwent TPSB for the following indications: prior negative transrectal biopsy (TRB; 174 men); primary biopsy in men at risk of sepsis (153); further evaluation after low-risk disease diagnosed based on a 12-core TRB (307). RESULTS: Prostate cancer was found in 36% of men after a negative TRB; 17% of these had disease solely in anterior sectors. As a primary diagnostic strategy, prostate cancer was diagnosed in 54% of men (median PSA level was 7.4 ng/mL). Of men with Gleason 3+3 disease on TRB, 29% were upgraded and went on to have radical treatment. Postoperative urinary retention occurred in 11 (1.7%) men, two secondary to clots. Per-urethral bleeding requiring hospital stay occurred in two men. There were no cases of urosepsis. CONCLUSIONS: TPSB of the prostate has a role in defining disease previously missed or under-diagnosed by TRB. The procedure has low morbidity.
OBJECTIVE: To describe a protocol for transperineal sector biopsies (TPSB) of the prostate and present the clinical experience of this technique in a UK population. PATIENTS AND METHODS: A retrospective review of a single-centre experience of TPSB approach was undertaken that preferentially, but not exclusively, targeted the peripheral zone of the prostate with 24-38 cores using a 'sector plan'. Procedures were carried out under general anaesthetic in most patients. Between January 2007 and August 2011, 634 consecutive patients underwent TPSB for the following indications: prior negative transrectal biopsy (TRB; 174 men); primary biopsy in men at risk of sepsis (153); further evaluation after low-risk disease diagnosed based on a 12-core TRB (307). RESULTS:Prostate cancer was found in 36% of men after a negative TRB; 17% of these had disease solely in anterior sectors. As a primary diagnostic strategy, prostate cancer was diagnosed in 54% of men (median PSA level was 7.4 ng/mL). Of men with Gleason 3+3 disease on TRB, 29% were upgraded and went on to have radical treatment. Postoperative urinary retention occurred in 11 (1.7%) men, two secondary to clots. Per-urethral bleeding requiring hospital stay occurred in two men. There were no cases of urosepsis. CONCLUSIONS: TPSB of the prostate has a role in defining disease previously missed or under-diagnosed by TRB. The procedure has low morbidity.
Authors: Findlay MacAskill; Su-Min Lee; David Eldred-Evans; Wahyu Wulaningsih; Rick Popert; Konrad Wolfe; Mieke Van Hemelrijck; Giles Rottenberg; Sidath H Liyanage; Peter Acher Journal: Int Urol Nephrol Date: 2017-05-05 Impact factor: 2.370
Authors: Lana Pepdjonovic; Guan Hee Tan; Sean Huang; Sarah Mann; Mark Frydenberg; Daniel Moon; Uri Hanegbi; Adam Landau; Ross Snow; Jeremy Grummet Journal: World J Urol Date: 2016-12-16 Impact factor: 4.226
Authors: Vassilios M Skouteris; E David Crawford; Vladimir Mouraviev; Paul Arangua; Marios Panagiotis Metsinis; Michael Skouteris; George Zacharopoulos; Nelson N Stone Journal: Rev Urol Date: 2018
Authors: Martin J Magers; Tianyu Zhan; Aaron M Udager; John T Wei; Scott A Tomlins; Angela J Wu; Lakshmi P Kunju; Madelyn Lew; Felix Y Feng; Daniel A Hamstra; Javed Siddiqui; Arul M Chinnaiyan; Jeffrey S Montgomery; Alon Z Weizer; Todd M Morgan; Brent K Hollenbeck; David C Miller; Ganesh S Palapattu; Hui Jiang; Rohit Mehra Journal: Med Oncol Date: 2015-10-06 Impact factor: 3.064