Literature DB >> 24051150

Lethal liquorice lollies (liquorice abuse causing pseudohyperaldosteronism).

B J Flores-Robles1, A R Hurtarte Sandoval, J D Penate Dardon, C Alonso Blas.   

Abstract

A 47-year-old woman was admitted to the emergency department with a history of asthenia, periorbital and lower limbs oedema, associated with hypokalaemia and increased blood pressure levels. Metabolic and renal causes were initially investigated as thyroid disease, Cushing syndrome and tubulopathies were excluded during the first week of admission. However, further questioning of the patient, revealed that she had been consuming several sachets of raw liquorice lollies (ignored amount) obtained from a herbalist a month ago. Based on the history and clinical findings, liquorice poisoning was highly suspected; an apparent mineralocorticoid excess secondary to ingestion of liquorice. Afterwards, levels of aldosterone and plasma renin activity were measured and found low 3 weeks later; therefore, our clinical suspicion was established. During the patient's stay at the hospital, liquorice was stopped and potassium supplements were started. Subsequently, a week after, the patient fully recovered without any significant sequelae.

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Year:  2013        PMID: 24051150      PMCID: PMC3794299          DOI: 10.1136/bcr-2013-201007

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  10 in total

1.  How to diagnose and treat a licorice-induced syndrome with findings similar to that of primary hyperaldosteronism.

Authors:  Eiji Kusano
Journal:  Intern Med       Date:  2004-01       Impact factor: 1.271

2.  Licorice-induced hypermineralocorticoidism.

Authors:  R V Farese; E G Biglieri; C H Shackleton; I Irony; R Gomez-Fontes
Journal:  N Engl J Med       Date:  1991-10-24       Impact factor: 91.245

3.  Further studies on the mechanism of the mineralocorticoid action of licorice in humans.

Authors:  D Armanini; S Lewicka; C Pratesi; M Scali; M C Zennaro; S Zovato; C Gottardo; M Simoncini; A Spigariol; V Zampollo
Journal:  J Endocrinol Invest       Date:  1996-10       Impact factor: 4.256

4.  A hypokalemic muscular weakness after licorice ingestion: a case report.

Authors:  Akkas Camkurt Meltem; Coskun Figen; Metin Aksu Nalan; Kunt Mahir; Bozkurt Sebnem; Isildak Mehlika; Kilic Ahmet Kasim; Bayraktar Miyase
Journal:  Cases J       Date:  2009-09-17

5.  Licorice abuse: time to send a warning message.

Authors:  Hesham R Omar; Irina Komarova; Mohamed El-Ghonemi; Ahmed Fathy; Rania Rashad; Hany D Abdelmalak; Muralidhar Reddy Yerramadha; Yaseen Ali; Engy Helal; Enrico M Camporesi
Journal:  Ther Adv Endocrinol Metab       Date:  2012-08       Impact factor: 3.565

6.  An autopsy case of licorice-induced hypokalemic rhabdomyolysis associated with acute renal failure: special reference to profound calcium deposition in skeletal and cardiac muscle.

Authors:  T Saito; Y Tsuboi; G Fujisawa; N Sakuma; K Honda; K Okada; K Saito; S Ishikawa; T Saito
Journal:  Nihon Jinzo Gakkai Shi       Date:  1994-11

7.  The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient.

Authors:  A Janse; M van Iersel; W H L Hoefnagels; M G M Olde Rikker
Journal:  Neth J Med       Date:  2005-04       Impact factor: 1.422

8.  Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars.

Authors:  Christine Johns
Journal:  CJEM       Date:  2009-01       Impact factor: 2.410

9.  Pseudohyperaldosteronism, liquorice, and hypertension.

Authors:  Bruno Sontia; Jan Mooney; Lise Gaudet; Rhian M Touyz
Journal:  J Clin Hypertens (Greenwich)       Date:  2008-02       Impact factor: 3.738

10.  Low renin hypertension.

Authors:  Manisha Sahay; Rakesh K Sahay
Journal:  Indian J Endocrinol Metab       Date:  2012-09
  10 in total
  8 in total

Review 1.  The association between consistent licorice ingestion, hypertension and hypokalaemia: a systematic review and meta-analysis.

Authors:  R Penninkilampi; E M Eslick; G D Eslick
Journal:  J Hum Hypertens       Date:  2017-06-29       Impact factor: 3.012

Review 2.  The clinical significance and costs of herbs and food supplements used by complementary and alternative medicine for the treatment of cardiovascular diseases and hypertension.

Authors:  S G Chrysant
Journal:  J Hum Hypertens       Date:  2015-05-21       Impact factor: 3.012

Review 3.  Food Products That May Cause an Increase in Blood Pressure.

Authors:  Marcin Adamczak; Andrzej Wiecek
Journal:  Curr Hypertens Rep       Date:  2020-01-08       Impact factor: 5.369

4.  Hypertension induced by liquorice tea.

Authors:  Emily Allcock; James Cowdery
Journal:  BMJ Case Rep       Date:  2015-06-15

5.  Hypokalaemia and drinking green tea: a literature review and report of 2 cases.

Authors:  Sebastian Jen Kin Chong; Kerry Antoinette Howard; Chloe Knox
Journal:  BMJ Case Rep       Date:  2016-02-16

6.  The Pharmacological Effects of Benachio-F(®) on Rat Gastrointestinal Functions.

Authors:  Bijay Kumar Poudel; Jae Young Yu; Yong Sam Kwon; Hyoung Geun Park; Miwon Son; Joon Ho Jun; Jeong Ah Kim; Jong Oh Kim
Journal:  Biomol Ther (Seoul)       Date:  2015-07-01       Impact factor: 4.634

Review 7.  11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome.

Authors:  Matthew A Bailey
Journal:  Curr Hypertens Rep       Date:  2017-11-14       Impact factor: 5.369

Review 8.  Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice.

Authors:  Changchao Huan; Yao Xu; Wei Zhang; Tingting Guo; Haochun Pan; Song Gao
Journal:  Front Pharmacol       Date:  2021-07-06       Impact factor: 5.810

  8 in total

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