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Literature DB >> 24049168

Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing.

Michael J Strong¹, Tina O'Grady, Zhen Lin, Guorong Xu, Melody Baddoo, Chris Parsons, Kun Zhang, Christopher M Taylor, Erik K Flemington.

Abstract

Comprehensive virome analysis of RNA sequence (RNA-seq) data sets from 118 non-Hodgkin's B-cell lymphomas revealed a small subset that is positive for Epstein-Barr virus (EBV) or human herpesvirus 6B (HHV-6B), with one coinfection. EBV transcriptome analysis revealed expression of the latency genes RPMS1, LMP1, and LMP2, with one sample additionally showing a high level of early lytic expression and another sample showing a high level of EBNA2 expression. HHV-6B transcriptome analysis revealed that the majority of genes were transcribed.

Entities: Disease Gene Species

Mesh：

Substances：
Viral Proteins

Year: 2013 PMID： 24049168 PMCID： PMC3838131 DOI： 10.1128/JVI.02380-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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