Literature DB >> 22206863

Role of EBNA1 in NPC tumourigenesis.

Lori Frappier1.   

Abstract

EBNA1 is expressed in all NPC tumours and is the only Epstein-Barr virus protein needed for the stable persistence of EBV episomes. EBNA1 binds to specific sequences in the EBV genome to facilitate the initiation of DNA synthesis, ensure the even distribution of the viral episomes to daughter cells during mitosis and to activate the transcription of other viral latency genes important for cell immortalization. In addition, EBNA1 has been found to alter cellular pathways in multiple ways that likely contribute to cell immortalization and malignant transformation. This chapter discusses the known functions and cellular effects of EBNA1, especially as pertains to NPC. Copyright Â
© 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22206863     DOI： 10.1016/j.semcancer.2011.12.002

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  28 in total

1.  An Epstein-Barr virus mutant produces immunogenic defective particles devoid of viral DNA.

Authors:  Sophia Pavlova; Regina Feederle; Kathrin Gärtner; Walter Fuchs; Harald Granzow; Henri-Jacques Delecluse
Journal:  J Virol       Date:  2012-12-12       Impact factor: 5.103

2.  Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer.

Authors:  Sheila Mansouri; Qun Pan; Benjamin J Blencowe; Julie M Claycomb; Lori Frappier
Journal:  J Virol       Date:  2014-07-16       Impact factor: 5.103

3.  Prognostic Significance of Granuloma and Amyloid Deposition in Nasopharyngeal Carcinoma.

Authors:  Yi-Chan Lee; Li-Yu Lee; Ngan-Ming Tsang; Cheng-Lung Hsu; Li-Jen Hsin; Tseng-Tong Kuo; Kai-Ping Chang
Journal:  Head Neck Pathol       Date:  2020-06-19

4.  Nasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis.

Authors:  Liangru Ke; Hufeng Zhou; Chong Wang; Geng Xiong; Yanqun Xiang; Yihong Ling; Abdelmajid Khabir; George S Tsao; Yixin Zeng; Musheng Zeng; Pierre Busson; Elliott Kieff; Xiang Guo; Bo Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-22       Impact factor: 11.205

5.  Ribosome Protein L4 is essential for Epstein-Barr Virus Nuclear Antigen 1 function.

Authors:  Chih-Lung Shen; Cheng-Der Liu; Ren-In You; Yung-Hao Ching; Jun Liang; Liangru Ke; Ya-Lin Chen; Hong-Chi Chen; Hao-Jen Hsu; Je-Wen Liou; Elliott Kieff; Chih-Wen Peng
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

6.  Proteomic profiling of EBNA1-host protein interactions in latent and lytic Epstein-Barr virus infections.

Authors:  Natasha Malik-Soni; Lori Frappier
Journal:  J Virol       Date:  2012-04-11       Impact factor: 5.103

7.  Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.

Authors:  Jennifer Yinuo Cao; Kathy Shire; Cameron Landry; Gerald D Gish; Tony Pawson; Lori Frappier
Journal:  Mol Cell Biol       Date:  2013-11-11       Impact factor: 4.272

8.  Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing.

Authors:  Michael J Strong; Tina O'Grady; Zhen Lin; Guorong Xu; Melody Baddoo; Chris Parsons; Kun Zhang; Christopher M Taylor; Erik K Flemington
Journal:  J Virol       Date:  2013-09-18       Impact factor: 5.103

Review 9.  The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma.

Authors:  Chi Man Tsang; Sai Wah Tsao
Journal:  Virol Sin       Date:  2015-04-21       Impact factor: 4.327

10.  Therapeutic vaccination against the rhesus lymphocryptovirus EBNA-1 homologue, rhEBNA-1, elicits T cell responses to novel epitopes in rhesus macaques.

Authors:  Eduardo L V Silveira; Mark H Fogg; Rachel M Leskowitz; Hildegund C Ertl; Roger W Wiseman; David H O'Connor; Paul Lieberman; Fred Wang; Francois Villinger
Journal:  J Virol       Date:  2013-10-02       Impact factor: 5.103
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