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Literature DB >> 24048521

All signals lost.

Abstract

Inhibitors of bacterial histidine kinases that globally deactivate bacterial signaling may offer a new offensive against antibiotic resistance.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 24048521 PMCID： PMC4480370 DOI： 10.1126/scitranslmed.3006670

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956

25 in total

Review 1. GHKL, an emergent ATPase/kinase superfamily.

Authors: R Dutta; M Inouye
Journal: Trends Biochem Sci Date: 2000-01 Impact factor: 13.807

2. Nucleotide binding by the histidine kinase CheA.

Authors: A M Bilwes; C M Quezada; L R Croal; B R Crane; M I Simon
Journal: Nat Struct Biol Date: 2001-04

3. A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin.

Authors: Gerald W Tannock; Karen Munro; Corinda Taylor; Blair Lawley; Wayne Young; Brendan Byrne; Judy Emery; Thomas Louie
Journal: Microbiology (Reading) Date: 2010-08-19 Impact factor: 2.777

Review 4. Screening strategies to identify new antibiotics.

Authors: Mark S Butler; Matthew A Cooper
Journal: Curr Drug Targets Date: 2012-03 Impact factor: 3.465

Review 5. Two-component signal transduction as potential drug targets in pathogenic bacteria.

Authors: Yasuhiro Gotoh; Yoko Eguchi; Takafumi Watanabe; Sho Okamoto; Akihiro Doi; Ryutaro Utsumi
Journal: Curr Opin Microbiol Date: 2010-02-04 Impact factor: 7.934

Review 6. Challenges of antibacterial discovery.

Authors: Lynn L Silver
Journal: Clin Microbiol Rev Date: 2011-01 Impact factor: 26.132

7. A high-throughput TNP-ATP displacement assay for screening inhibitors of ATP-binding in bacterial histidine kinases.

Authors: Michael T Guarnieri; Brian S J Blagg; Rui Zhao
Journal: Assay Drug Dev Technol Date: 2010-11-04 Impact factor: 1.738

8. Activity-based probe for histidine kinase signaling.

Authors: Kaelyn E Wilke; Samson Francis; Erin E Carlson
Journal: J Am Chem Soc Date: 2012-05-24 Impact factor: 15.419

9. Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism.

Authors: A Marina; C Mott; A Auyzenberg; W A Hendrickson; C D Waldburger
Journal: J Biol Chem Date: 2001-08-07 Impact factor: 5.157

10. Probing kinase and phosphatase activities of two-component systems in vivo with concentration-dependent phosphorylation profiling.

Authors: Rong Gao; Ann M Stock
Journal: Proc Natl Acad Sci U S A Date: 2012-12-24 Impact factor: 11.205

8 in total

1. Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.

Authors: Robert M Immormino; Chrystal A Starbird; Ruth E Silversmith; Robert B Bourret
Journal: Biochemistry Date: 2015-05-28 Impact factor: 3.162

All signals lost.

Review 1. GHKL, an emergent ATPase/kinase superfamily.

2. Nucleotide binding by the histidine kinase CheA.

3. A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin.

Review 4. Screening strategies to identify new antibiotics.

Review 5. Two-component signal transduction as potential drug targets in pathogenic bacteria.

Review 6. Challenges of antibacterial discovery.

7. A high-throughput TNP-ATP displacement assay for screening inhibitors of ATP-binding in bacterial histidine kinases.

8. Activity-based probe for histidine kinase signaling.

9. Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism.

10. Probing kinase and phosphatase activities of two-component systems in vivo with concentration-dependent phosphorylation profiling.

1. Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.

2. Screening serine/threonine and tyrosine kinase inhibitors for histidine kinase inhibition.

3. Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases.

4. Synergism between the Synthetic Antibacterial and Antibiofilm Peptide (SAAP)-148 and Halicin.

5. Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus.

6. Inactivation of multiple bacterial histidine kinases by targeting the ATP-binding domain.

Review 7. Recent Advances in Histidine Kinase-Targeted Antimicrobial Agents.

Review 8. Roles of Two-Component Signal Transduction Systems in Shigella Virulence.