BACKGROUND: Alzheimer's disease constitutes one of the main causes of dementia. It is clinically characterized by memory impairment, deterioration of intellectual faculties and loss of professional skills. Furthermore changes in equilibrium and limb coordination are clinically demonstrable in persons with Alzheimer's disease. In the present study we tried to figure out possible changes of the Purkinje cells in Alzheimer's disease brains. SUBJECTS AND METHODS: We studied the Purkinje cells from the vermis of the cerebellum in 5 Alzheimer' disease brains Golgi technique. RESULTS: In the Purkinje cells from the inferior surface of the cerebellar hemispheres severe dendritic and spinal pathology consisting of loss of distal dendritic segments and alterations of dendritic spine morphology can be noticed in Alzheimer's disease brains. CONCLUSIONS: The morphological and morphometric estimation of the dendrites and the dendritic spines of the Purkinje cells from the inferior surface of the cerebellar hemispheres in Alzheimer's disease brains revealed substantial alterations of the dendritic arborization and marked loss of the dendritic spines, which may be related to cognitive impairment and motor deficits in Alzheimer's disease.
BACKGROUND:Alzheimer's disease constitutes one of the main causes of dementia. It is clinically characterized by memory impairment, deterioration of intellectual faculties and loss of professional skills. Furthermore changes in equilibrium and limb coordination are clinically demonstrable in persons with Alzheimer's disease. In the present study we tried to figure out possible changes of the Purkinje cells in Alzheimer's disease brains. SUBJECTS AND METHODS: We studied the Purkinje cells from the vermis of the cerebellum in 5 Alzheimer' disease brains Golgi technique. RESULTS: In the Purkinje cells from the inferior surface of the cerebellar hemispheres severe dendritic and spinal pathology consisting of loss of distal dendritic segments and alterations of dendritic spine morphology can be noticed in Alzheimer's disease brains. CONCLUSIONS: The morphological and morphometric estimation of the dendrites and the dendritic spines of the Purkinje cells from the inferior surface of the cerebellar hemispheres in Alzheimer's disease brains revealed substantial alterations of the dendritic arborization and marked loss of the dendritic spines, which may be related to cognitive impairment and motor deficits in Alzheimer's disease.
Authors: Nora E Gray; Jonathan A Zweig; Colleen Kawamoto; Joseph F Quinn; Philip F Copenhaver Journal: J Alzheimers Dis Date: 2016 Impact factor: 4.472
Authors: Bob Jacobs; Nicholas L Johnson; Devin Wahl; Matthew Schall; Busisiwe C Maseko; Albert Lewandowski; Mary A Raghanti; Bridget Wicinski; Camilla Butti; William D Hopkins; Mads F Bertelsen; Timothy Walsh; John R Roberts; Roger L Reep; Patrick R Hof; Chet C Sherwood; Paul R Manger Journal: Front Neuroanat Date: 2014-04-23 Impact factor: 3.856
Authors: Emma M Perkins; Daumante Suminaite; Yvonne L Clarkson; Sin Kwan Lee; Alastair R Lyndon; Jeffrey D Rothstein; David J A Wyllie; Kohichi Tanaka; Mandy Jackson Journal: Hum Mol Genet Date: 2016-10-15 Impact factor: 6.150
Authors: Emma M Perkins; Yvonne L Clarkson; Daumante Suminaite; Alastair R Lyndon; Kohichi Tanaka; Jeffrey D Rothstein; Paul A Skehel; David J A Wyllie; Mandy Jackson Journal: Hum Mol Genet Date: 2018-08-01 Impact factor: 6.150