OBJECTIVES: To pathologically distinguish mesothelioma from lung carcinoma, particularly adenocarcinoma. METHODS: We conducted immunohistochemical analyses on clinical specimens, including 26 cases of mesothelioma, 28 cases of lung adenocarcinoma, and 33 cases of lung squamous cell carcinoma. RESULTS: We found that CD90 expression was useful in making a differential diagnosis between epithelioid mesothelioma and lung adenocarcinoma, whereas sarcomatoid mesothelioma and lung carcinoma specimens, irrespective of the histologic types, were negative in general. The sensitivity and specificity of CD90 expression in epithelioid mesothelioma and lung adenocarcinoma were comparable to those of well-established markers used for the differential diagnosis. CONCLUSIONS: These data collectively indicate that CD90 is a novel diagnostic marker that contributes to a diagnosis of epithelioid mesothelioma.
OBJECTIVES: To pathologically distinguish mesothelioma from lung carcinoma, particularly adenocarcinoma. METHODS: We conducted immunohistochemical analyses on clinical specimens, including 26 cases of mesothelioma, 28 cases of lung adenocarcinoma, and 33 cases of lung squamous cell carcinoma. RESULTS: We found that CD90 expression was useful in making a differential diagnosis between epithelioid mesothelioma and lung adenocarcinoma, whereas sarcomatoid mesothelioma and lung carcinoma specimens, irrespective of the histologic types, were negative in general. The sensitivity and specificity of CD90 expression in epithelioid mesothelioma and lung adenocarcinoma were comparable to those of well-established markers used for the differential diagnosis. CONCLUSIONS: These data collectively indicate that CD90 is a novel diagnostic marker that contributes to a diagnosis of epithelioid mesothelioma.
Authors: Nurhan Sahin; Ayse Nur Akatli; Muhammet Reha Celik; Hakkı Ulutas; Emine Turkmen Samdanci; Cemil Colak Journal: Pathol Oncol Res Date: 2016-10-19 Impact factor: 3.201
Authors: Moshe Lapidot; Abigail E Case; Dalia Larios; Helen I Gandler; Chengcheng Meng; Isidora Tošić; Ellen L Weisberg; Michael J Poitras; Prafulla C Gokhale; Cloud P Paweletz; Klaus Podar; Ravi Salgia; Srinivas V Saladi; James D Griffin; David A Frank; Raphael Bueno; Martin Sattler Journal: Cancers (Basel) Date: 2020-12-22 Impact factor: 6.639