Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Brd4 shields chromatin from ATM kinase signaling storms.

Literature DB >> 24045152

Brd4 shields chromatin from ATM kinase signaling storms.

Abstract

Upon activation, ataxia telangiectasia mutated (ATM) kinase rapidly phosphorylates hundreds of proteins, setting off chaotic signaling storms from areas of damaged chromatin. Recent work by Kaidi and Jackson and Floyd et al. advance our knowledge of the mechanisms that initiate or limit ATM kinase signaling storms at chromatin.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 24045152 PMCID： PMC3936316 DOI： 10.1126/scisignal.2004622

Source DB: PubMed Journal: Sci Signal ISSN： 1945-0877 Impact factor: 8.192

12 in total

1. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

Authors: Yingli Sun; Xiaofeng Jiang; Shujuan Chen; Norvin Fernandes; Brendan D Price
Journal: Proc Natl Acad Sci U S A Date: 2005-09-02 Impact factor: 11.205

2. The Mre11 complex is required for ATM activation and the G2/M checkpoint.

Authors: Christian T Carson; Rachel A Schwartz; Travis H Stracker; Caroline E Lilley; Darwin V Lee; Matthew D Weitzman
Journal: EMBO J Date: 2003-12-15 Impact factor: 11.598

3. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

Authors: Christopher J Bakkenist; Michael B Kastan
Journal: Nature Date: 2003-01-30 Impact factor: 49.962

4. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.

Authors: Ji-Hoon Lee; Tanya T Paull
Journal: Science Date: 2004-04-02 Impact factor: 47.728

5. Requirement of the MRN complex for ATM activation by DNA damage.

Authors: Tamar Uziel; Yaniv Lerenthal; Lilach Moyal; Yair Andegeko; Leonid Mittelman; Yosef Shiloh
Journal: EMBO J Date: 2003-10-15 Impact factor: 11.598

6. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Authors: Shuhei Matsuoka; Bryan A Ballif; Agata Smogorzewska; E Robert McDonald; Kristen E Hurov; Ji Luo; Corey E Bakalarski; Zhenming Zhao; Nicole Solimini; Yaniv Lerenthal; Yosef Shiloh; Steven P Gygi; Stephen J Elledge
Journal: Science Date: 2007-05-25 Impact factor: 47.728

7. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Authors: Scott R Floyd; Michael E Pacold; Qiuying Huang; Scott M Clarke; Fred C Lam; Ian G Cannell; Bryan D Bryson; Jonathan Rameseder; Michael J Lee; Emily J Blake; Anna Fydrych; Richard Ho; Benjamin A Greenberger; Grace C Chen; Amanda Maffa; Amanda M Del Rosario; David E Root; Anne E Carpenter; William C Hahn; David M Sabatini; Clark C Chen; Forest M White; James E Bradner; Michael B Yaffe
Journal: Nature Date: 2013-06-02 Impact factor: 49.962

8. ATM controls meiotic double-strand-break formation.

Authors: Julian Lange; Jing Pan; Francesca Cole; Michael P Thelen; Maria Jasin; Scott Keeney
Journal: Nature Date: 2011-10-16 Impact factor: 49.962

9. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

Authors: Yingli Sun; Xiaofeng Jiang; Ye Xu; Marina K Ayrapetov; Lisa A Moreau; Johnathan R Whetstine; Brendan D Price
Journal: Nat Cell Biol Date: 2009-09-27 Impact factor: 28.824

10. KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.

Authors: Abderrahmane Kaidi; Stephen P Jackson
Journal: Nature Date: 2013-05-26 Impact factor: 49.962

9 in total

1. ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer.

Authors: Christopher J Bakkenist; James J Lee; John C Schmitz
Journal: Clin Colorectal Cancer Date: 2018-09-13 Impact factor: 4.481

2. Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.

Authors: Tatiana N Moiseeva; Armin M Gamper; Brian L Hood; Thomas P Conrads; Christopher J Bakkenist
Journal: DNA Repair (Amst) Date: 2016-05-07

Brd4 shields chromatin from ATM kinase signaling storms.

1. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

2. The Mre11 complex is required for ATM activation and the G2/M checkpoint.

3. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

4. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.

5. Requirement of the MRN complex for ATM activation by DNA damage.

6. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

7. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

8. ATM controls meiotic double-strand-break formation.

9. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

10. KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.

1. ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer.

2. Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.

Review 3. Involvement of Brd4 in different steps of the papillomavirus life cycle.

4. LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.

Review 5. In silico analysis of protein Lys-N(𝜀)-acetylation in plants.

Review 6. The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis.

Review 7. Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer.

8. Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA.

9. ATM protein is deficient in over 40% of lung adenocarcinomas.