| Literature DB >> 24042071 |
Hai-Ying Yang1, Yu-Hong Gao2, De-Yun Niu1, Li-Yin Yang1, Xue-Mei Gao1, Gang Du3, Qiu-Fen Hu4.
Abstract
Three new xanthones, 1,5-dihydroxy-3-hydroxyethyl-6-methoxycarbonylxanthone (1), 1-hydroxy-5- methoxy-3-hydroxyethyl-6-methoxycarbonylxanthone (2), and 1-hydroxy-3-hydroxyethyl- 8-ethoxycarbonylxanthone (3), along with seven known xanthones (4-10) were isolated from the fermentation products of an endophytic fungus Phomopsis sp.. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1-10 were also tested for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) by MTT method using paclitaxel as positive control. Compounds 1 and 3 showed cytotoxicity against A549 cell lines with IC50 values of 3.6 and 2.5 μM, respectively. In addition, 1 was cytotoxic to MCF7 cells with IC50 value of 2.7 μM.Entities:
Keywords: 1,5-dihydroxy-3-hydroxyethyl-6-methoxycarbonylxanthone;1-hydroxy-5-methoxy-3-hydroxyethyl-6-methoxycarbonylxanthone;1-hydroxy-3-hydroxyethyl-8-ethoxycarbonylxanthone; 1,7-dihydroxy-2-methoxy-3-(3-methylbut-2-enyl)xanthone;1-hydroxy-4,7-dimethoxy-6-(3-oxobutyl) xanthone; 6-O- methyl-2-deprenylrheediaxanthone B; Asperxanthone (PubChem CID: 5748546); Cytotoxicity; Phomopsis sp; Pinselin (PubChem CID: 5377796); Secosterigmatocystin; Structure elucidation; Xanthones
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Year: 2013 PMID： 24042071 DOI： 10.1016/j.fitote.2013.09.004
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882