| Literature DB >> 240418 |
H Wajcman, J V Kilmartin, A Najman, D Labie.
Abstract
Hemoglobin Cochin Port-Royal beta 146 (HC3) His yields Arg is the second example in which the beta C-terminal residue is replaced. Owing to the known importance of His beta 146 in the co-operative effects of hemoglobin, the functional properties of this variant were carefully studied. It had a normal Hill coefficient but a reduced alkaline Bohr effect. However, the reduction in Bohr effect is less than the halving predicted from previous mutants and modified hemoglobins.Entities:
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Year: 1975 PMID： 240418 DOI： 10.1016/0005-2795(75)90191-9
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002