Literature DB >> 24039257

Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction.

Susanne Herold1, Nieves M Gabrielli, István Vadász.   

Abstract

In this review we summarize recent major advances in our understanding on the molecular mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary barrier dysfunction, highlighting the role of immune cells, inflammatory and noninflammatory signaling events, mechanical noxae, and the affected cellular and molecular entities and functions. Furthermore, we address novel aspects of resolution and repair of ALI, as well as putative candidates for treatment of ALI, including pharmacological and cellular therapeutic means.

Entities:  

Keywords:  alveolar-capillary barrier dysfunction; molecular mechanism; pharmacological and cell-based therapy; pulmonary edema; zaacute lung injury/acute respiratory distress syndrome

Mesh：

Year:  2013        PMID： 24039257     DOI： 10.1152/ajplung.00232.2013

Source DB:  PubMed          Journal:  Am J Physiol Lung Cell Mol Physiol        ISSN： 1040-0605            Impact factor:   5.464


  78 in total

Review 1.  Platelets in the pathogenesis of acute respiratory distress syndrome.

Authors:  Hemang Yadav; Daryl J Kor
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-08-28       Impact factor: 5.464

2.  TGF-β inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin.

Authors:  Luciana C Mazzocchi; Christine U Vohwinkel; Konstantin Mayer; Susanne Herold; Rory E Morty; Werner Seeger; István Vadász
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2017-07-13       Impact factor: 5.464

Review 3.  A critical review of the American Journal of Physiology-Lung Cellular and Molecular Physiology: 2012-2015.

Authors:  Sadis Matalon
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2014-11-07       Impact factor: 5.464

Review 4.  Novel regulators of endothelial barrier function.

Authors:  Dolly Mehta; Krishnan Ravindran; Wolfgang M Kuebler
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2014-11-07       Impact factor: 5.464

5.  MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway.

Authors:  MinJie Ju; BoFei Liu; HongYu He; ZhunYong Gu; YiMei Liu; Ying Su; DuMing Zhu; Jing Cang; Zhe Luo
Journal:  Cell Cycle       Date:  2018-09-19       Impact factor: 4.534

6.  Glucose-6-phosphate dehydrogenase inhibition attenuates acute lung injury through reduction in NADPH oxidase-derived reactive oxygen species.

Authors:  A Nadeem; N O Al-Harbi; S F Ahmad; K E Ibrahim; N Siddiqui; M M Al-Harbi
Journal:  Clin Exp Immunol       Date:  2018-01-21       Impact factor: 4.330

7.  Exosomes from iPSCs Delivering siRNA Attenuate Intracellular Adhesion Molecule-1 Expression and Neutrophils Adhesion in Pulmonary Microvascular Endothelial Cells.

Authors:  Zhihai Ju; Jinhui Ma; Chen Wang; Jie Yu; Yeru Qiao; Feilong Hei
Journal:  Inflammation       Date:  2017-04       Impact factor: 4.092

Review 8.  Ubiquitin-proteasome signaling in lung injury.

Authors:  Natalia D Magnani; Laura A Dada; Jacob I Sznajder
Journal:  Transl Res       Date:  2018-04-23       Impact factor: 7.012

9.  3-Methyladenine and dexmedetomidine reverse lipopolysaccharide-induced acute lung injury through the inhibition of inflammation and autophagy.

Authors:  Dengfeng Ding; Shiyuan Xu; Hongfei Zhang; Wei Zhao; Xueping Zhang; Yuanxu Jiang; Ping Wang; Zhongliang Dai; Junzhi Zhang
Journal:  Exp Ther Med       Date:  2018-02-02       Impact factor: 2.447

10.  NOX1 is responsible for cell death through STAT3 activation in hyperoxia and is associated with the pathogenesis of acute respiratory distress syndrome.

Authors:  Stephanie Carnesecchi; Isabelle Dunand-Sauthier; Filippo Zanetti; Grigory Singovski; Christine Deffert; Yves Donati; Thomas Cagarelli; Jean-Claude Pache; Karl-Heinz Krause; Walter Reith; Constance Barazzone-Argiroffo
Journal:  Int J Clin Exp Pathol       Date:  2014-01-15
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