BACKGROUND:Long-term survival (LTS) in patients (pts) with pancreatic cancer is still uncommon, little data is available to identify long-term survivors. The CONKO-001 study, which established gemcitabine after resection as adjuvant therapy, may provide data to answer this question. METHODS: CONKO-001 pts with an overall survival ≥5 years were compared to those who survived <5 years. Central re-evaluation of primary histology was performed. Univariate analysis with the χ(2) -test identified qualifying factors. Logistic regression was used to investigate the influence of these covariates on LTS. RESULTS: Of the evaluable 354 CONKO-001 pts, 54 (15%) with an overall survival ≥5 years were identified. It was possible to obtain tumor specimens of 39 pts (72%). Histological re-evaluation confirmed adenocarcinoma in 38 pts, 1 showed a high-grade neuroendocrine tumor. Univariate analysis for all 53 LTS pts with adenocarcinoma compared to the remaining 300 non-LTS pts revealed as relevant active treatment, tumor grading, tumor size, lymph nodes. No significance could be demonstrated for resection margin, sex, age, Karnofsky performance status, CA 19-9 at study entry. In multivariate analysis, tumor grading, active treatment, tumor size, lymph node involvement were independent prognostic factors for LTS. CONCLUSION: Long-term survival can be achieved in adenocarcinoma of the pancreas.
RCT Entities:
BACKGROUND: Long-term survival (LTS) in patients (pts) with pancreatic cancer is still uncommon, little data is available to identify long-term survivors. The CONKO-001 study, which established gemcitabine after resection as adjuvant therapy, may provide data to answer this question. METHODS: CONKO-001 pts with an overall survival ≥5 years were compared to those who survived <5 years. Central re-evaluation of primary histology was performed. Univariate analysis with the χ(2) -test identified qualifying factors. Logistic regression was used to investigate the influence of these covariates on LTS. RESULTS: Of the evaluable 354 CONKO-001 pts, 54 (15%) with an overall survival ≥5 years were identified. It was possible to obtain tumor specimens of 39 pts (72%). Histological re-evaluation confirmed adenocarcinoma in 38 pts, 1 showed a high-grade neuroendocrine tumor. Univariate analysis for all 53 LTS pts with adenocarcinoma compared to the remaining 300 non-LTS pts revealed as relevant active treatment, tumor grading, tumor size, lymph nodes. No significance could be demonstrated for resection margin, sex, age, Karnofsky performance status, CA 19-9 at study entry. In multivariate analysis, tumor grading, active treatment, tumor size, lymph node involvement were independent prognostic factors for LTS. CONCLUSION: Long-term survival can be achieved in adenocarcinoma of the pancreas.
Authors: Marco Dal Molin; Ming Zhang; Roeland F de Wilde; Niki A Ottenhof; Neda Rezaee; Christopher L Wolfgang; Amanda Blackford; Bert Vogelstein; Kenneth W Kinzler; Nickolas Papadopoulos; Ralph H Hruban; Anirban Maitra; Laura D Wood Journal: Clin Cancer Res Date: 2015-01-26 Impact factor: 12.531
Authors: Christina L Roland; Anthony D Yang; Matthew H G Katz; Deyali Chatterjee; Huamin Wang; Heather Lin; Jean N Vauthey; Peter W Pisters; Gauri R Varadhachary; Robert A Wolff; Christopher H Crane; Jeffrey E Lee; Jason B Fleming Journal: Ann Surg Oncol Date: 2014-10-29 Impact factor: 5.344
Authors: Michael Fanous; Adib Keikhosravi; Andre Kajdacsy-Balla; Kevin W Eliceiri; Gabriel Popescu Journal: Biomed Opt Express Date: 2020-02-12 Impact factor: 3.732
Authors: Alexander P Stark; Greg D Sacks; Matthew M Rochefort; Timothy R Donahue; Howard A Reber; James S Tomlinson; David W Dawson; Guido Eibl; O Joe Hines Journal: Surgery Date: 2016-02-02 Impact factor: 3.982
Authors: Ching-Wei D Tzeng; Hop S Tran Cao; Jeffrey E Lee; Peter W T Pisters; Gauri R Varadhachary; Robert A Wolff; James L Abbruzzese; Christopher H Crane; Douglas B Evans; Huamin Wang; Daniel E Abbott; Jean-Nicolas Vauthey; Thomas A Aloia; Jason B Fleming; Matthew H G Katz Journal: J Gastrointest Surg Date: 2013-11-16 Impact factor: 3.452