Literature DB >> 32206415

Quantitative phase imaging of stromal prognostic markers in pancreatic ductal adenocarcinoma.

Michael Fanous1,2, Adib Keikhosravi3, Andre Kajdacsy-Balla4, Kevin W Eliceiri3,5, Gabriel Popescu1,2.   

Abstract

New quantitative prognostic markers are needed for improved pancreatic ductal adenocarcinoma (PDAC) prognosis. Second harmonic generation microscopy has been used to show that collagen fiber alignment in PDAC is a negative prognostic factor. In this work, a series of PDAC and normal adjacent tissue (NAT) biopsies were imaged with spatial light interference microscopy (SLIM). Quantitative analysis performed on the biopsy SLIM images show that PDAC fiber structures have lower alignment per unit length, narrower width, and are longer than NAT controls. Importantly, fibrillar collagen in PDAC shows an inverse relationship between survival data and fiber width and length (p < 0.05).
© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.

Entities:  

Year:  2020        PMID： 32206415      PMCID： PMC7075600          DOI： 10.1364/BOE.383242

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN： 2156-7085            Impact factor:   3.732


  42 in total

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Journal:  Cancer Res       Date:  2014-06-01       Impact factor: 12.701

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Journal:  Mod Pathol       Date:  2011-04-29       Impact factor: 7.842

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Review 4.  Modeling tissue morphogenesis and cancer in 3D.

Authors:  Kenneth M Yamada; Edna Cukierman
Journal:  Cell       Date:  2007-08-24       Impact factor: 41.582

Review 5.  Tumor mechanics and metabolic dysfunction.

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Journal:  Free Radic Biol Med       Date:  2014-12-19       Impact factor: 7.376

6.  Diagnosis of gastrointestinal tract lesions by endoscopic ultrasound-guided fine-needle aspiration biopsy.

Authors:  Martin R Vander Noot; Mohamad A Eloubeidi; Victor K Chen; Isam Eltoum; Darshana Jhala; Nirag Jhala; Sujath Syed; David C Chhieng
Journal:  Cancer       Date:  2004-06-25       Impact factor: 6.860

7.  Collagen reorganization at the tumor-stromal interface facilitates local invasion.

Authors:  Paolo P Provenzano; Kevin W Eliceiri; Jay M Campbell; David R Inman; John G White; Patricia J Keely
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9.  Label-free optical quantification of structural alterations in Alzheimer's disease.

Authors:  Moosung Lee; Eeksung Lee; JaeHwang Jung; Hyeonseung Yu; Kyoohyun Kim; Jonghee Yoon; Shinhwa Lee; Yong Jeong; YongKeun Park
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10.  Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells.

Authors:  Han Sang Park; Matthew T Rinehart; Katelyn A Walzer; Jen-Tsan Ashley Chi; Adam Wax
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  7 in total

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Authors:  Chenfei Hu; Mikhail E Kandel; Young Jae Lee; Gabriel Popescu
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2.  Spatial light interference microscopy: principle and applications to biomedicine.

Authors:  Xi Chen; Mikhail E Kandel; Gabriel Popescu
Journal:  Adv Opt Photonics       Date:  2021-05-05       Impact factor: 24.750

3.  Fabrication and Bonding of Refractive Index Matched Microfluidics for Precise Measurements of Cell Mass.

Authors:  Edward R Polanco; Justin Griffin; Thomas A Zangle
Journal:  Polymers (Basel)       Date:  2021-02-05       Impact factor: 4.329

4.  Monitoring reactivation of latent HIV by label-free gradient light interference microscopy.

Authors:  Neha Goswami; Yiyang Lu; Mikhail E Kandel; Michael J Fanous; Kathrin Bohn-Wippert; Erin N Tevonian; Roy D Dar; Gabriel Popescu
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5.  Label-free SARS-CoV-2 detection and classification using phase imaging with computational specificity.

Authors:  Neha Goswami; Yuchen R He; Yu-Heng Deng; Chamteut Oh; Nahil Sobh; Enrique Valera; Rashid Bashir; Nahed Ismail; Hyunjoon Kong; Thanh H Nguyen; Catherine Best-Popescu; Gabriel Popescu
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6.  Computational interference microscopy enabled by deep learning.

Authors:  Yuheng Jiao; Yuchen R He; Mikhail E Kandel; Xiaojun Liu; Wenlong Lu; Gabriel Popescu
Journal:  APL Photonics       Date:  2021-04-06

7.  High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition.

Authors:  Ankit Butola; Daria Popova; Dilip K Prasad; Azeem Ahmad; Anowarul Habib; Jean Claude Tinguely; Purusotam Basnet; Ganesh Acharya; Paramasivam Senthilkumaran; Dalip Singh Mehta; Balpreet Singh Ahluwalia
Journal:  Sci Rep       Date:  2020-08-04       Impact factor: 4.379
  7 in total

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