Literature DB >> 24034900

Rapid and simultaneous detection of the chlorhexidine and mupirocin resistance genes qacA/B and mupA in clinical isolates of methicillin-resistant Staphylococcus aureus.

Patrick Mc Gann1, Michael Milillo, Yoon I Kwak, Reyes Quintero, Paige E Waterman, Emil Lesho.   

Abstract

We describe a real-time PCR-based assay capable of simultaneously detecting femA (Staphylococcus aureus-specific), mecA (methicillin resistance), qacA/B (chlorhexidine tolerance), and mupA (high-level mupirocin resistance) from bacterial cells in less than 90 minutes. The assay was validated with 1968 clinical MRSA submitted to a surveillance network.
© 2013.

Entities:  

Keywords:  Chlorhexidine; MRSA; MupA; Mupirocin; QacA

Mesh：

Substances：

Year:  2013        PMID： 24034900     DOI： 10.1016/j.diagmicrobio.2013.06.006

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  16 in total

1.  Prevalence of chlorhexidine-resistant methicillin-resistant Staphylococcus aureus following prolonged exposure.

Authors:  Carey D Schlett; Eugene V Millar; Katrina B Crawford; Tianyuan Cui; Jeffrey B Lanier; David R Tribble; Michael W Ellis
Journal:  Antimicrob Agents Chemother       Date:  2014-05-19       Impact factor: 5.191

2.  Recurrent Methicillin-Resistant Staphylococcus aureus Cutaneous Abscesses and Selection of Reduced Chlorhexidine Susceptibility during Chlorhexidine Use.

Authors:  Ryan C Johnson; Carey D Schlett; Katrina Crawford; Jeffrey B Lanier; D Scott Merrell; Michael W Ellis
Journal:  J Clin Microbiol       Date:  2015-08-19       Impact factor: 5.948

3.  MRSA prevalence rates detected in a tertiary care hospital in Austria and successful treatment of MRSA positive patients applying a decontamination regime with octenidine.

Authors:  G Pichler; C Pux; R Babeluk; B Hermann; E Stoiser; A De Campo; A Grisold; I Zollner-Schwetz; R Krause; W Schippinger
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-08-28       Impact factor: 3.267

4.  Multidrug and Mupirocin Resistance in Environmental Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates from Homes of People Diagnosed with Community-Onset MRSA Infection.

Authors:  J H Shahbazian; P D Hahn; S Ludwig; J Ferguson; P Baron; A Christ; K Spicer; P Tolomeo; A M Torrie; W B Bilker; V C Cluzet; B Hu; K Julian; I Nachamkin; S C Rankin; D O Morris; E Lautenbach; M F Davis
Journal:  Appl Environ Microbiol       Date:  2017-10-31       Impact factor: 4.792

Review 5.  Review and phylogenetic analysis of qac genes that reduce susceptibility to quaternary ammonium compounds in Staphylococcus species.

Authors:  Trudy M Wassenaar; David Ussery; Lene N Nielsen; Hanne Ingmer
Journal:  Eur J Microbiol Immunol (Bp)       Date:  2015-03-26

6.  Novel Multiplex PCR Assay for Detection of Chlorhexidine-Quaternary Ammonium, Mupirocin, and Methicillin Resistance Genes, with Simultaneous Discrimination of Staphylococcus aureus from Coagulase-Negative Staphylococci.

Authors:  Jo-Ann McClure; Johanna Zaal DeLongchamp; John M Conly; Kunyan Zhang
Journal:  J Clin Microbiol       Date:  2017-04-05       Impact factor: 5.948

7.  Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus.

Authors:  Richard Copin; William E Sause; Yi Fulmer; Divya Balasubramanian; Sophie Dyzenhaus; Jamil M Ahmed; Krishan Kumar; John Lees; Anna Stachel; Jason C Fisher; Karl Drlica; Michael Phillips; Jeffrey N Weiser; Paul J Planet; Anne-Catrin Uhlemann; Deena R Altman; Robert Sebra; Harm van Bakel; Jennifer Lighter; Victor J Torres; Bo Shopsin
Journal:  Proc Natl Acad Sci U S A       Date:  2019-01-11       Impact factor: 11.205

8.  Topical Antibiotic Use Coselects for the Carriage of Mobile Genetic Elements Conferring Resistance to Unrelated Antimicrobials in Staphylococcus aureus.

Authors:  Glen P Carter; Mark B Schultz; Sarah L Baines; Anders Gonçalves da Silva; Helen Heffernan; Audrey Tiong; Peter H Pham; Ian R Monk; Timothy P Stinear; Benjamin P Howden; Deborah A Williamson
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

9.  Consumption of Chlorhexidine and Mupirocin Across the Health System of the US Department of Defense (DOD) and the Incidence of the qacA/B and mupA Genes in the DOD Facilities of the National Capital Region.

Authors:  Mackenzie Morgan; Patrick McGann; Sarah Gierhart; Uzo Chukwuma; Douglas Richesson; Mary Hinkle; Emil Lesho
Journal:  Clin Infect Dis       Date:  2017-06-15       Impact factor: 9.079

Review 10.  Assessing the Potential for Unintended Microbial Consequences of Routine Chlorhexidine Bathing for Prevention of Healthcare-associated Infections.

Authors:  Ahmed Babiker; Joseph D Lutgring; Scott Fridkin; Mary K Hayden
Journal:  Clin Infect Dis       Date:  2021-03-01       Impact factor: 9.079
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