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Literature DB >> 24033276

Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters.

Nicholas Clay¹, Kwanghyun Baek², Artem Shkumatov³, Mei-Hsiu Lai¹, Cartney E Smith¹, Max Rich¹, Hyunjoon Kong¹.

Abstract

This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of cell tracking and therapies.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 24033276 PMCID： PMC3872536 DOI： 10.1021/am4030998

Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229

37 in total

1. Quantitative study of electroporation-mediated molecular uptake and cell viability.

Authors: P J Canatella; J F Karr; J A Petros; M R Prausnitz
Journal: Biophys J Date: 2001-02 Impact factor: 4.033

2. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.

Authors: L Josephson; C H Tung; A Moore; R Weissleder
Journal: Bioconjug Chem Date: 1999 Mar-Apr Impact factor: 4.774

Review 3. Modulation of membrane traffic by mechanical stimuli.

Authors: Gerard Apodaca
Journal: Am J Physiol Renal Physiol Date: 2002-02

4. Relaxivity optimization of a PEGylated iron-oxide-based negative magnetic resonance contrast agent for T₂-weighted spin-echo imaging.

Authors: Elmar Pöselt; Hauke Kloust; Ulrich Tromsdorf; Marcus Janschel; Christoph Hahn; Christoph Maßlo; Horst Weller
Journal: ACS Nano Date: 2012-01-31 Impact factor: 15.881

5. Non-viral gene delivery regulated by stiffness of cell adhesion substrates.

Authors: Hyun Joon Kong; Jodi Liu; Kathryn Riddle; Takuya Matsumoto; Kent Leach; David J Mooney
Journal: Nat Mater Date: 2005-05-15 Impact factor: 43.841

6. Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging.

Authors: Xiaoqiang Yang; Jamison J Grailer; Ian J Rowland; Alireza Javadi; Samuel A Hurley; Douglas A Steeber; Shaoqin Gong
Journal: Biomaterials Date: 2010-09-09 Impact factor: 12.479

7. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.

Authors: Norased Nasongkla; Erik Bey; Jimin Ren; Hua Ai; Chalermchai Khemtong; Jagadeesh Setti Guthi; Shook-Fong Chin; A Dean Sherry; David A Boothman; Jinming Gao
Journal: Nano Lett Date: 2006-11 Impact factor: 11.189

8. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents.

Authors: Joseph A Frank; Brad R Miller; Ali S Arbab; Holly A Zywicke; E Kay Jordan; Bobbi K Lewis; L Henry Bryant; Jeff W M Bulte
Journal: Radiology Date: 2003-06-20 Impact factor: 11.105

Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters.

1. Quantitative study of electroporation-mediated molecular uptake and cell viability.

2. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.

Review 3. Modulation of membrane traffic by mechanical stimuli.

4. Relaxivity optimization of a PEGylated iron-oxide-based negative magnetic resonance contrast agent for T₂-weighted spin-echo imaging.

5. Non-viral gene delivery regulated by stiffness of cell adhesion substrates.

6. Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging.

7. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.

8. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents.

9. Integrin targeting using RGD-PEI conjugates for in vitro gene transfer.

10. Polyelectrolyte coating of iron oxide nanoparticles for MRI-based cell tracking.

1. Hydrophilic packaging of iron oxide nanoclusters for highly sensitive imaging.

Review 2. Engineering the Surface of Therapeutic "Living" Cells.