Literature DB >> 24029934

Cell-based therapies for myocardial repair: emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart.

Jose S Da Silva1, Joshua M Hare.   

Abstract

Accumulating data support the use of bone marrow (BM)-derived MSCs in animal models (e.g., swine) to restore cardiac function and tissue perfusion in chronic cardiac injury. Based on results obtained in swine, we are currently conducting phase I/II clinical trials to address the safety, cell type, cell dose, delivery technique, and efficacy of MSCs in patients with chronic heart failure. MSCs for these trials are isolated from harvested BM and then processed and expanded for intracardiac injection. The BM-MSCs in use for the clinical trials are of clinical grade having been processed successfully in an FDA-approved cGMP facility.

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Mesh：

Year:  2013        PMID： 24029934     DOI： 10.1007/978-1-62703-505-7_8

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

1.  Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) trial.

Authors:  Vasileios Karantalis; Darcy L DiFede; Gary Gerstenblith; Si Pham; James Symes; Juan Pablo Zambrano; Joel Fishman; Pradip Pattany; Ian McNiece; John Conte; Steven Schulman; Katherine Wu; Ashish Shah; Elayne Breton; Janice Davis-Sproul; Richard Schwarz; Gary Feigenbaum; Muzammil Mushtaq; Viky Y Suncion; Albert C Lardo; Ivan Borrello; Adam Mendizabal; Tomer Z Karas; John Byrnes; Maureen Lowery; Alan W Heldman; Joshua M Hare
Journal:  Circ Res       Date:  2014-02-24       Impact factor: 17.367

2.  Synergistic Effects of Combined Cell Therapy for Chronic Ischemic Cardiomyopathy.

Authors:  Vasileios Karantalis; Viky Y Suncion-Loescher; Luiza Bagno; Samuel Golpanian; Ariel Wolf; Cristina Sanina; Courtney Premer; Anthony J Kanelidis; Frederic McCall; Bo Wang; Wayne Balkan; Jose Rodriguez; Marcos Rosado; Azorides Morales; Konstantinos Hatzistergos; Makoto Natsumeda; Irene Margitich; Ivonne Hernandez Schulman; Samirah A Gomes; Muzammil Mushtaq; Darcy L DiFede; Joel E Fishman; Pradip Pattany; Juan Pablo Zambrano; Alan W Heldman; Joshua M Hare
Journal:  J Am Coll Cardiol       Date:  2015-11-03       Impact factor: 24.094

3.  Enhancing effect of glucose microspheres in the viability of human mesenchymal stem cell suspensions for clinical administration.

Authors:  Patricia Gálvez; Maria J Martín; Ana C Calpena; Juan A Tamayo; Maria A Ruiz; Beatriz Clares
Journal:  Pharm Res       Date:  2014-06-25       Impact factor: 4.200

4.  Rationale and design of the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy (the POSEIDON-DCM study): a phase I/II, randomized pilot study of the comparative safety and efficacy of transendocardial injection of autologous mesenchymal stem cell vs. allogeneic mesenchymal stem cells in patients with non-ischemic dilated cardiomyopathy.

Authors:  Muzammil Mushtaq; Darcy L DiFede; Samuel Golpanian; Aisha Khan; Samirah A Gomes; Adam Mendizabal; Alan W Heldman; Joshua M Hare
Journal:  J Cardiovasc Transl Res       Date:  2014-10-30       Impact factor: 4.132

Review 5.  Stem Cell Therapies for Restorative Treatments of Central Nervous System Ischemia-Reperfusion Injury.

Authors:  Ge Li; Ping Zhu; Qi-Song Su; Dong-Lin Zhuang; Moussa Ide Nasser; Xiyalatu Sai; Gang Deng
Journal:  Cell Mol Neurobiol       Date:  2022-02-07       Impact factor: 5.046

6.  Harnessing Epicardial Progenitor Cells and Their Derivatives for Rescue and Repair of Cardiac Tissue After Myocardial Infarction.

Authors:  Krithika S Rao; Jeffrey L Spees
Journal:  Curr Mol Biol Rep       Date:  2017-07-15

7.  Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial.

Authors:  Alan W Heldman; Darcy L DiFede; Joel E Fishman; Juan P Zambrano; Barry H Trachtenberg; Vasileios Karantalis; Muzammil Mushtaq; Adam R Williams; Viky Y Suncion; Ian K McNiece; Eduard Ghersin; Victor Soto; Gustavo Lopera; Roberto Miki; Howard Willens; Robert Hendel; Raul Mitrani; Pradip Pattany; Gary Feigenbaum; Behzad Oskouei; John Byrnes; Maureen H Lowery; Julio Sierra; Mariesty V Pujol; Cindy Delgado; Phillip J Gonzalez; Jose E Rodriguez; Luiza Lima Bagno; Didier Rouy; Peter Altman; Cheryl Wong Po Foo; Jose da Silva; Erica Anderson; Richard Schwarz; Adam Mendizabal; Joshua M Hare
Journal:  JAMA       Date:  2014-01-01       Impact factor: 56.272

8.  Allogeneic Mesenchymal Stem Cells Restore Endothelial Function in Heart Failure by Stimulating Endothelial Progenitor Cells.

Authors:  Courtney Premer; Arnon Blum; Michael A Bellio; Ivonne Hernandez Schulman; Barry E Hurwitz; Meela Parker; Christopher R Dermarkarian; Darcy L DiFede; Wayne Balkan; Aisha Khan; Joshua M Hare
Journal:  EBioMedicine       Date:  2015-03-28       Impact factor: 8.143

9.  The impact of patient sex on the response to intramyocardial mesenchymal stem cell administration in patients with non-ischaemic dilated cardiomyopathy.

Authors:  Victoria Florea; Angela C Rieger; Makoto Natsumeda; Bryon A Tompkins; Monisha N Banerjee; Ivonne H Schulman; Courtney Premer; Aisha Khan; Krystalenia Valasaki; Bettina Heidecker; Alejandro Mantero; Wayne Balkan; Raul D Mitrani; Joshua M Hare
Journal:  Cardiovasc Res       Date:  2020-11-01       Impact factor: 10.787

10.  Human Amnion-Derived Mesenchymal Stromal Cells in Cirrhotic Patients with Refractory Ascites: A Possible Anti-Inflammatory Therapy for Preventing Spontaneous Bacterial Peritonitis.

Authors:  Mariangela Pampalone; Simona Corrao; Giandomenico Amico; Giampiero Vitale; Rossella Alduino; Pier Giulio Conaldi; Giada Pietrosi
Journal:  Stem Cell Rev Rep       Date:  2021-01-03       Impact factor: 5.739
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