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Literature DB >> 24026096

Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.

Abstract

The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

Entities: Disease Gene Species

Keywords: Hippo signaling; LATS1; LATS2; human cancer; protein kinase

Mesh：

Substances：

Year: 2013 PMID： 24026096 PMCID： PMC3813850 DOI： 10.1534/genetics.113.156372

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

11 in total

1. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway.

Authors: Qun-Ying Lei; Heng Zhang; Bin Zhao; Zheng-Yu Zha; Feng Bai; Xin-Hai Pei; Shimin Zhao; Yue Xiong; Kun-Liang Guan
Journal: Mol Cell Biol Date: 2008-01-28 Impact factor: 4.272

Review 2. The Hippo pathway: regulators and regulations.

Authors: Fa-Xing Yu; Kun-Liang Guan
Journal: Genes Dev Date: 2013-02-15 Impact factor: 11.361

3. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.

Authors: M A St John; W Tao; X Fei; R Fukumoto; M L Carcangiu; D G Brownstein; A F Parlow; J McGrath; T Xu
Journal: Nat Genet Date: 1999-02 Impact factor: 38.330

4. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.

Authors: W Tao; S Zhang; G S Turenchalk; R A Stewart; M A St John; W Chen; T Xu
Journal: Nat Genet Date: 1999-02 Impact factor: 38.330

5. Tumor suppressor LATS1 is a negative regulator of oncogene YAP.

Authors: Yawei Hao; Alex Chun; Kevin Cheung; Babak Rashidi; Xiaolong Yang
Journal: J Biol Chem Date: 2007-12-24 Impact factor: 5.157

6. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

Authors: R W Justice; O Zilian; D F Woods; M Noll; P J Bryant
Journal: Genes Dev Date: 1995-03-01 Impact factor: 11.361

7. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

Authors: Bin Zhao; Xiaomu Wei; Weiquan Li; Ryan S Udan; Qian Yang; Joungmok Kim; Joe Xie; Tsuneo Ikenoue; Jindan Yu; Li Li; Pan Zheng; Keqiang Ye; Arul Chinnaiyan; Georg Halder; Zhi-Chun Lai; Kun-Liang Guan
Journal: Genes Dev Date: 2007-11-01 Impact factor: 11.361

8. An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases.

Authors: Johannes Bischof; Robert K Maeda; Monika Hediger; François Karch; Konrad Basler
Journal: Proc Natl Acad Sci U S A Date: 2007-02-22 Impact factor: 11.205

Review 9. The Hippo pathway and human cancer.

Authors: Kieran F Harvey; Xiaomeng Zhang; David M Thomas
Journal: Nat Rev Cancer Date: 2013-03-07 Impact factor: 60.716

10. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.

Authors: T Xu; W Wang; S Zhang; R A Stewart; W Yu
Journal: Development Date: 1995-04 Impact factor: 6.868

20 in total

1. Expression of LATS1 contributes to good prognosis and can negatively regulate YAP oncoprotein in non-small-cell lung cancer.

Authors: Xu-Yong Lin; Xiu-Peng Zhang; Jun-Hua Wu; Xue-Shan Qiu; En-Hua Wang
Journal: Tumour Biol Date: 2014-03-29

2. LATS2 promoter hypermethylation and its effect on gene expression in human breast cancer.

Authors: Saki Matsui; Naofumi Kagara; Chieko Mishima; Yasuto Naoi; Masafumi Shimoda; Atsushi Shimomura; Kenzo Shimazu; Seung Jin Kim; Shinzaburo Noguchi
Journal: Oncol Lett Date: 2017-12-06 Impact factor: 2.967

3. YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells.

Authors: Namrata Bora-Singhal; Jonathan Nguyen; Courtney Schaal; Deepak Perumal; Sandeep Singh; Domenico Coppola; Srikumar Chellappan
Journal: Stem Cells Date: 2015-06 Impact factor: 6.277

4. MicroRNA-135b regulates apoptosis and chemoresistance in colorectal cancer by targeting large tumor suppressor kinase 2.

Authors: Yuqi He; Jianxun Wang; Jiheng Wang; Victoria Yee-Wa Yung; Emily Hsu; Aiqin Li; Qian Kang; Junbiao Ma; Qingfeng Han; Peng Jin; Rui Xing; Youyong Lu; Jianqiu Sheng
Journal: Am J Cancer Res Date: 2015-03-15 Impact factor: 6.166