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Literature DB >> 25179841

MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2.

Shujun Feng¹, Wenjing Pan, Ye Jin, Jianhua Zheng.

Abstract

Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies suggest that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC and a potentially novel diagnostic and therapeutic target for OC treatment.

Entities: Chemical

Mesh：

Substances：

Year: 2014 PMID： 25179841 DOI： 10.1007/s13277-014-2546-0

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

26 in total

1. MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer.

Authors: Haiyan Zhang; Zhi Zuo; Xin Lu; Li Wang; Haiyan Wang; Zhiling Zhu
Journal: Oncol Rep Date: 2011-11-08 Impact factor: 3.906

Review 2. LATS tumor suppressor: a new governor of cellular homeostasis.

Authors: Stacy Visser; Xiaolong Yang
Journal: Cell Cycle Date: 2010-10-20 Impact factor: 4.534

3. Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis.

Authors: Xiaoming Dai; Peilu She; Fangtao Chi; Ying Feng; Huan Liu; Daqing Jin; Yiqiang Zhao; Xiaocan Guo; Dandan Jiang; Kun-Liang Guan; Tao P Zhong; Bin Zhao
Journal: J Biol Chem Date: 2013-10-08 Impact factor: 5.157

Review 4. The role of miR-148a in gastric cancer.

Authors: Jiazeng Xia; Xiaoqiang Guo; Jiang Yan; Kaiyuan Deng
Journal: J Cancer Res Clin Oncol Date: 2014-09 Impact factor: 4.553

Review 5. Noncoding RNAs in endocrine malignancy.

Authors: Jessica Kentwell; Justin S Gundara; Stan B Sidhu
Journal: Oncologist Date: 2014-04-09

6. MiR-25 promotes gastric cancer cells growth and motility by targeting RECK.

Authors: Hongying Zhao; Yu Wang; Liu Yang; Rongke Jiang; Wenqing Li
Journal: Mol Cell Biochem Date: 2014-01 Impact factor: 3.396

7. MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma.

Authors: Xiaohui Xu; Zhaoli Chen; Xiaohong Zhao; Jiwen Wang; Dapeng Ding; Zhen Wang; Fengwei Tan; Xiaogang Tan; Fang Zhou; Jian Sun; Nan Sun; Yibo Gao; Kang Shao; Ning Li; Bin Qiu; Jie He
Journal: Biochem Biophys Res Commun Date: 2012-03-17 Impact factor: 3.575

8. MiR-195 regulates cell apoptosis of human hepatocellular carcinoma cells by targeting LATS2.

Authors: Xiaoyan Yang; Jia Yu; Jie Yin; Qiong Xiang; Huifang Tang; Xiaoyong Lei
Journal: Pharmazie Date: 2012-07 Impact factor: 1.267

9. Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.

Authors: Jacob J Adler; Derrick E Johnson; Brigitte L Heller; Lauren R Bringman; William P Ranahan; Michael D Conwell; Yang Sun; Andy Hudmon; Clark D Wells
Journal: Proc Natl Acad Sci U S A Date: 2013-10-07 Impact factor: 11.205

10. Upregulation of microRNA-203 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer.

Authors: Shaosheng Wang; Xiaohong Zhao; Jie Wang; Yingmei Wen; Linjing Zhang; Dezhu Wang; Huili Chen; Qiuxia Chen; Wei Xiang
Journal: Med Oncol Date: 2013-08-07 Impact factor: 3.064

33 in total

1. MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression.

Authors: Jianting Long; Caiwen Ou; Haoming Xia; Yifan Zhu; Dayue Liu
Journal: Tumour Biol Date: 2015-06-06

2. LATS2 promoter hypermethylation and its effect on gene expression in human breast cancer.

Authors: Saki Matsui; Naofumi Kagara; Chieko Mishima; Yasuto Naoi; Masafumi Shimoda; Atsushi Shimomura; Kenzo Shimazu; Seung Jin Kim; Shinzaburo Noguchi
Journal: Oncol Lett Date: 2017-12-06 Impact factor: 2.967

3. The clinical significance and biological function of large tumour suppressor 2 in hepatocellular carcinoma.

Authors: Rong Liang; Yan Lin; Chun-Ling Yuan; Zhi-Hui Liu; Yong-Qiang Li; Xiao-Ling Luo; Jia-Zhou Ye; Hai-Hong Ye
Journal: Cell Prolif Date: 2017-03-01 Impact factor: 6.831

4. Increased expression of microRNA-196a predicts poor prognosis in human ovarian carcinoma.

Authors: Yi Fan; Jin Fan; Liu Huang; Ming Ye; Zheng Huang; Yibin Wang; Qiufen Li; Jiezhen Huang
Journal: Int J Clin Exp Pathol Date: 2015-04-01

5. miR-25 promotes glioblastoma cell proliferation and invasion by directly targeting NEFL.

Authors: Gang Peng; Xianrui Yuan; Jian Yuan; Qing Liu; Minhui Dai; Chenfu Shen; Jianrong Ma; Yiwei Liao; Weixi Jiang
Journal: Mol Cell Biochem Date: 2015-07-26 Impact factor: 3.396

6. MicroRNA-133b inhibits proliferation and invasion of ovarian cancer cells through Akt and Erk1/2 inactivation by targeting epidermal growth factor receptor.

Authors: Xiaoqin Liu; Guohong Li
Journal: Int J Clin Exp Pathol Date: 2015-09-01

7. miR-25 is upregulated before the occurrence of esophageal squamous cell carcinoma.

Authors: Yaxu Jia; Heng Lu; Cheng Wang; Junjun Wang; Chenyu Zhang; Fangyu Wang; Chunni Zhang
Journal: Am J Transl Res Date: 2017-10-15 Impact factor: 4.060

Review 8. Small molecules targeting microRNA for cancer therapy: Promises and obstacles.

Authors: Di Wen; Michael Danquah; Amit Kumar Chaudhary; Ram I Mahato
Journal: J Control Release Date: 2015-08-06 Impact factor: 9.776

9. miR-25 expression is upregulated in pancreatic ductal adenocarcinoma and promotes cell proliferation by targeting ABI2.

Authors: Huimin Lu; Ling Zhang; Shan Lu; Dujiang Yang; Jun Ye; Mao Li; Weiming Hu
Journal: Exp Ther Med Date: 2020-03-11 Impact factor: 2.447

10. Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.

Authors: Aleksandra Toloczko; Fusheng Guo; Hiu-Fung Yuen; Qing Wen; Stephen A Wood; Yan Shan Ong; Pei Yi Chan; Asfa Alli Shaik; Jayantha Gunaratne; Mark J Dunne; Wanjin Hong; Siew Wee Chan
Journal: Cancer Res Date: 2017-07-18 Impact factor: 12.701