BACKGROUND: The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their relationship to cerebrospinal fluid (CSF) biomarkers. METHODS: Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA). RESULTS: BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid β42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04). CONCLUSIONS: Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration.
BACKGROUND: The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their relationship to cerebrospinal fluid (CSF) biomarkers. METHODS:Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA). RESULTS:BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid β42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04). CONCLUSIONS: Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration.
Authors: Kamalini G Ranasinghe; Cathrine Petersen; Kiwamu Kudo; Danielle Mizuiri; Katherine P Rankin; Gil D Rabinovici; Maria Luisa Gorno-Tempini; William W Seeley; Salvatore Spina; Bruce L Miller; Keith Vossel; Lea T Grinberg; Srikantan S Nagarajan Journal: Alzheimers Dement Date: 2021-04-21 Impact factor: 21.566