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Literature DB >> 24022092

Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation.

Janine K Tom¹, Rock J Mancini, Aaron P Esser-Kahn.

Abstract

We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulating constructs provided greater stimulation of NF-κB in a model cell line and bone marrow-derived dendritic cells than the components unconjugated in solution.

Entities: CellLine Chemical Disease Gene Species

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Year: 2013 PMID： 24022092 PMCID： PMC4399865 DOI： 10.1039/c3cc45468a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

41 in total

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Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation.

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