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Literature DB >> 22411781

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function.

Bruno G De Geest¹, Monique A Willart, Bart N Lambrecht, Charlotte Pollard, Chris Vervaet, Jean Paul Remon, Johan Grooten, Stefaan De Koker.

Abstract

Immunizing: to evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments.

Entities: Chemical

Mesh：

Substances：

Year: 2012 PMID： 22411781 DOI： 10.1002/anie.201200048

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

15 in total

1. Coadministration of a Plasmid Encoding HIV-1 Gag Enhances the Efficacy of Cancer DNA Vaccines.

Authors: Laure Lambricht; Kevin Vanvarenberg; Ans De Beuckelaer; Lien Van Hoecke; Johan Grooten; Bernard Ucakar; Pascale Lipnik; Niek N Sanders; Stefan Lienenklaus; Véronique Préat; Gaëlle Vandermeulen
Journal: Mol Ther Date: 2016-06-20 Impact factor: 11.454

2. Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation.

Authors: Janine K Tom; Rock J Mancini; Aaron P Esser-Kahn
Journal: Chem Commun (Camb) Date: 2013-10-25 Impact factor: 6.222

Review 3. Biomimetic and synthetic interfaces to tune immune responses.

Authors: Anusha Garapaty; Julie A Champion
Journal: Biointerphases Date: 2015-09-15 Impact factor: 2.456

4. Self-Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation.

Authors: Michelle L Bookstaver; Krystina L Hess; Christopher M Jewell
Journal: Small Date: 2018-08-26 Impact factor: 13.281

5. pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation.

Authors: Lutz Nuhn; Nane Vanparijs; Ans De Beuckelaer; Lien Lybaert; Glenn Verstraete; Kim Deswarte; Stefan Lienenklaus; Nikunj M Shukla; Alex C D Salyer; Bart N Lambrecht; Johan Grooten; Sunil A David; Stefaan De Koker; Bruno G De Geest
Journal: Proc Natl Acad Sci U S A Date: 2016-07-05 Impact factor: 11.205

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function.

1. Coadministration of a Plasmid Encoding HIV-1 Gag Enhances the Efficacy of Cancer DNA Vaccines.

2. Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation.

Review 3. Biomimetic and synthetic interfaces to tune immune responses.

4. Self-Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation.

5. pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation.

6. Self-Assembly as a Molecular Strategy to Improve Immunotherapy.

Review 7. Nanoparticle approaches against bacterial infections.

8. Engineering release kinetics with polyelectrolyte multilayers to modulate TLR signaling and promote immune tolerance.

Review 9. Engineering synthetic vaccines using cues from natural immunity.

10. Design of Polyelectrolyte Multilayers to Promote Immunological Tolerance.