Lower fat and better quality diet therapy for children with pharmacoresistant epilepsy.

The ketogenic diet (KD) is an established, effective, nonpharmacologic treatment for children with pharmacoresistant epilepsy. Although the KD is the most well-established dietary therapy for epilepsy, it is too restrictive and is associated with serious complications; therefore, alternative lower-fat diets, including a modified Atkins diet and low-glycemic index diet, have been developed. Recent ongoing clinical evidence suggests that other dietary therapies have an efficacy almost comparable to that of the KD. In addition, a diet rich in polyunsaturated fatty acids appears to increase the efficacy of diet therapy and reduce the complications of a high-fat diet. Here, we review the systematic information about lower-fat diets and better-quality dietary therapies and the current clinical status of each of these dietary approaches.

Introduction

Fasting as a treatment for epilepsy was described in the New Testament of the Bible, and the earliest scientific approach was introduced by Geyelin in the 1920s1). Since its resurgence in the mid-1990s, the ketogenic diet (KD) has been used worldwide, including Korea, and is recognized as a valuable adjunct therapeutic modality2). The classic KD, with a nonfat-to-fat ratio of 1:4, necessitates a regimen that is high in fat, adequate in protein (1 g/kg/day), and low in carbohydrates. Since 1 g of fat produces 9 cal and 1 g of protein or carbohydrate produces 4 cal, when the ratio of constituents are calculated on a calorie scale, the ratio appears more exaggerated3) (Fig. 1). The KD is difficult to maintain due to its restrictive nature, and it has potentially serious complications. We require alternative diet therapies, including a modified Atkins diet (MAD), low-glycemic index diet (LGID), and a diet rich in polyunsaturated fatty acids (PUFAs), that are safer and more convenient to use and can improve the outcome.

Fig. 1

The ratio of diet composition of the classic ketogenic diet (A0, a modified Atkins diet (B), and low-glycemic index diet (C), compared to that of a regular diet (D) on a calorie scale.

Here, we discuss the systematic information and current clinical status of each of these dietary approaches.

What is the KD?

The composition of the KD is expressed by a 4:1 ratio of fat to protein and carbohydrate (by weight). The traditional long-chain fatty acid diet is the most common KD used4). The medium-chain triglyceride diet increases the palatability of the KD and is substantially more ketogenic than the classic KD, but is used less frequently because it often causes gastrointestinal (GI) problems5,6). However, the efficacy of seizure control in these diets is similar6). There is a large clinical database of evidence on the efficacy of the KD, and most studies show similar outcomes7-10). Our experience using the classic KD for 199 children with pharmacoresistant epilepsy suggests that after 12 months on the KD, approximately 41% of the children had at least a 50% reduction in the number of seizures and 25% of children were seizure-free8). Although the efficacy of the KD is not maintained in all patients after they discontinue the diet, the effects of the KD persist in most patients as seen by an alleviation of symptoms that appeared in the pre-KD administration period11). The widespread acceptance of the KD has ended the debate about its efficacy. However, despite this, many families and physicians are reluctant to use the KD because of its inherent difficulties as well as the various complications that can stem from the nutritionally unbalanced composition of the KD.

As a safer and more comfortable diet therapy, MAD or LGID could be considered. Fat is ketogenic and carbohydrate is antiketogenic. Therefore, these diets induce a state of ketosis by providing high fat and low carbohydrate, although they involve intake of large amounts of protein, which is restricted in the conventional KD8-10). Therefore, a more tolerable diet with a reduced risk of the complications is desired.

Complications of KD

Poor tolerability and the potentially serious complications of an unbalanced diet should be considered. Some adverse events occur within a few days or a month of diet initiation; other events may occur after several months. According to our experience using KD therapy at Severance Hospital12), the most common early onset complication is GI disturbances such as nausea/vomiting, diarrhea, and constipation. These complications are sometimes associated with gastritis and fat intolerance. Other early onset complications, in order of frequency, are hypertriglyceridemia; transient hyperuricemia, hypercholesterolemia, various infectious diseases, symptomatic hypoglycemia, hypoproteinemia, hypomagnesemia, repetitive hyponatremia, low concentrations of high-density lipoprotein, lipoid pneumonia due to aspiration, hepatitis, acute pancreatitis, and persistent metabolic acidosis. Late-onset complications also include osteopenia, renal stones, cardiomyopathy, secondary hypocarnitinemia, and iron-deficiency anemia. Most early and late-onset complications are transient and can be successfully managed by careful follow-up and conservative strategies. However, 22 of 129 patients (17.1%) stopped the KD due to various kinds of serious complications and 4 of 129 patients (3.1%) died during the KD: 2 from sepsis, 1 from cardiomyopathy, and 1 from lipoid pneumonia12). The KD is restrictive and has various complications; therefore, the use of other possible alternative lower-fat and better-quality diets, including the MAD, LGID, and a PUFA-rich diet, is encouraged.

MAD

The Atkins diet was created in the 1970s by the late Dr. Robert C. Atkins, as a means to combat obesity. It is nearly a balanced diet (60% fat, 30% protein, and 10% carbohydrate by weight, or 77% fat, 17% protein, and 6% carbohydrate by calorie) compared with the KD (80% fat, 15% protein, and 5% carbohydrate by weight, or 90% fat, 6% protein, 4% carbohydrate by calorie) (Fig. 1). The protocol of an MAD suggests that carbohydrates should be restricted to 10 g per day in the first month13). If a child has difficulty with this initial restricted amount, then an increase of 5 g per day is allowed for at least 1 month, to a maximum of 10% carbohydrates per day (by weight). Multivitamins, calcium, and vitamin D2 were administered as supplements. We recommended that patients consume 75% of their recommended daily calorie intake, which is different from the Hopkins protocol and similar to the conventional KD14). This recommendation was based on our previous experience, albeit anecdotal, of more favorable outcomes using the MAD with restricted calories14). In addition, we recommended that patients frequently measure urine ketone levels at home, especially when seizures occur or the frequency of the seizures increases. The patients' tolerability of the diet and complications were assessed using various methods, including laboratory evaluations, on a regular basis (Table 1).

Table 1

The suggested protocol of a modified Atkins diet at Severance Hospital

The most previous series showed striking similarities to large prospective and retrospective studies of the classic KD; however, we found a trend for a higher incidence of responders (>50% seizure reduction) in the KD group15), and the KD and MAD need to be compared in a well-controlled, randomized study in order to ensure a good evidence base for decisions in the usual situations. In contrast with the efficacy, there was no doubt about the tolerability of the MAD15-19). Therefore, a MAD diet is strongly recommended for patients who experience problems with the conventional KD, which was shown to be effective but too restrictive, as well as for patients who require a long-term diet therapy trial due to the presence of glucose transporter type 1-deficiency syndrome or selected mitochondrial diseases.

LGID

The glycemic index provides a measure of how quickly levels of glucose in the blood increase after consuming a particular type of food, relative to the consumption of pure glucose. Glycemic indices of various food are presented in Table 2. The LGID would reduce blood glucose by altering the quality and types of carbohydrates consumed. The LGID for refractory epilepsy was first reported by Pfeifer and Thiele20) in 2005. Glucose has a glycemic index of 100. In the LGID, foods are limited to those with a glycemic index of less than 50. Total carbohydrates are gradually decreased to 40-60 gm/day (~10% of daily calories). Approximately 20-30% of calories are from protein and 60-70% are from fat (Fig. 1). Muzykewicz et al.21) reported that a >50% reduction in seizure frequency in 76 patients was observed in 42%, 50%, 54%, and 66% of patients with follow-up available at 1, 3, 6, 9, and 12 months. The LGID seems to have efficacy similar to that seen in the KD observational studies, but there are no randomized controlled trials studies comparing the KD with the LGID. Thus, further studies are needed to evaluate and compare the efficacies of these diets.

Table 2

Glycemic indices of various foods

GI, glycemic index.

PUFA-enriched die

Fatty acids are the most important contributor to calories in the KD and are important for all aspects of efficacy and complications of the KD12). Unfortunately, however, most fatty acids in the conventional KD are saturated or monounsaturated because the diet is based primarily on butter, cream, and olive oil22). PUFAs are believed to favorably affect neuronal and cardiovascular function23).

There are 2 groups of PUFAs: n-3 and n-6 PUFAs. Among dietary n-3 PUFAs, alpha-linoleic acid (ALA) is found in flax seeds, walnuts, and almonds, and eicosapentaenoic acid and docosahexanoic acid are found in marine fish and seals. The primary n-3 PUFA in the brain is DHA, and it can be obtained directly from the diet or can be synthesized from ALA23). In addition, the conversion of ALA to DHA can be optimized when ALA is coadministered with the n-6 fatty acid LA at a 1:4 ratio, as observed in rat brains24). The n-6 PUFAs are found in vegetable oils such as canola and corn oil. Canola oil also has large amounts of n-3 and a 1:4 ratio of n-3 to n-6.

Recent evidence suggests that the KD may be useful in the treatment of epilepsy owing to the presence of PUFAs25). PUFAs stimulate mitochondrial biogenesis and enhance energy reserves, leading to stabilized synaptic function and improved seizure control. Clinically, Fraser et al.26) described 9 children on the KD whose elevated blood PUFAs were correlated with improved seizure control. Recently, we reported the case of a 7-year-old boy with Lennox-Gastaut syndrome combined with mitochondrial respiratory chain complex I deficiency, whose medically intractable seizures were successfully controlled with a PUFA-enriched MAD without any significant adverse events. The diet consists of canola oil and diverse menu items such as fish and nuts (instead of olive oil) and has an ideal 1:2.8 ratio of n-3 to n-6 (Table 3). In addition, some studies suggest that n-3 and n-6 PUFAs together may be clinically important for preventing cardiovascular disorders27). The ratio of n-3 to n-6 PUFAs is known to be important for maintaining cardiovascular health27). In our patient, a modified diet therapy with canola oil and a diverse menu resulted in an ideal ratio of n-3 to n-6 PUFAs of 1:2.8, and the diet is expected to decrease the risk for cardiovascular complications, even with long-term maintenance of the high-fat diet.

Table 3

Constituents of fatty acids in a modified Atkins diet of 1,200 kcal and ratio of fat to nonfat of 1.7:1 on pre- and post-PUFA-enriched diet

PUFAs, polyunsaturated fatty acids.

Conclusions

The ability of children with pharmacoresistant epilepsy to tolerate the MAD or LGID is encouraging, suggesting that this diet can replace the conventional KD, especially in patients who require long-term diet therapy trial due to the presence of glucose transporter type 1-deficiency syndrome or selected mitochondrial diseases, as well as in patients who experience problems with the conventional KD, which is effective but too restrictive. PUFA-enriched diet therapy is also expected to increase the efficacy of diet therapy and reduce complications of a high-fat diet in children with refractory epilepsy. However, there are few evidence-based studies that compare the conventional KD with the MAD, LGID, or PUFA-enriched diet, and such further studies are needed.