Elizabeth A Thiele1. 1. Pediatric Epilepsy Service, Departments of Neurology and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02115, USA. ethiele@partners.org
Abstract
PURPOSE: To evaluate the evidence for determining if the ketogenic diet is an effective treatment for epilepsy. METHODS: A literature review of published data over the past 80 years concerning the ketogenic diet was performed, focusing on efficacy, tolerability, age of patient population, as well as study design. RESULTS: There have been several studies involving prospective and retrospective studies showing the ketogenic diet to be a very efficacious treatment in epilepsy, particularly epilepsy in childhood. However, no Class 1 studies have been published concerning the efficacy of the ketogenic diet. CONCLUSIONS: The ketogenic diet appears to be a very effective treatment for epilepsy, particularly in childhood. It would be beneficial to have Class 1 studies available to help better define the role of the diet both in children and adults.
PURPOSE: To evaluate the evidence for determining if the ketogenic diet is an effective treatment for epilepsy. METHODS: A literature review of published data over the past 80 years concerning the ketogenic diet was performed, focusing on efficacy, tolerability, age of patient population, as well as study design. RESULTS: There have been several studies involving prospective and retrospective studies showing the ketogenic diet to be a very efficacious treatment in epilepsy, particularly epilepsy in childhood. However, no Class 1 studies have been published concerning the efficacy of the ketogenic diet. CONCLUSIONS: The ketogenic diet appears to be a very effective treatment for epilepsy, particularly in childhood. It would be beneficial to have Class 1 studies available to help better define the role of the diet both in children and adults.
Authors: Illana A Stanley; Sofia M Ribeiro; Alfredo Giménez-Cassina; Erik Norberg; Nika N Danial Journal: Trends Cell Biol Date: 2013-09-07 Impact factor: 20.808
Authors: Sudha Kilaru Kessler; Paul R Gallagher; Renée A Shellhaas; Robert R Clancy; A G Christina Bergqvist Journal: Epilepsy Res Date: 2011-02-23 Impact factor: 3.045