OBJECTIVE: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. METHOD: Identify the most common known polymorphisms of NAT*2 gene namely, G(191)A, C(282)T, C(341)T, C(481)T, G(590)A, A(803)G and G(857)A using PCR-RFLP analysis. RESULTS: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. CONCLUSION: A new allele variant containing G(590)A, C(282)T and T(341)C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.
OBJECTIVE: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. METHOD: Identify the most common known polymorphisms of NAT*2 gene namely, G(191)A, C(282)T, C(341)T, C(481)T, G(590)A, A(803)G and G(857)A using PCR-RFLP analysis. RESULTS: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. CONCLUSION: A new allele variant containing G(590)A, C(282)T and T(341)C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.
Authors: S B Liggett; L E Wagoner; L L Craft; R W Hornung; B D Hoit; T C McIntosh; R A Walsh Journal: J Clin Invest Date: 1998-10-15 Impact factor: 14.808
Authors: K P Vatsis; W W Weber; D A Bell; J M Dupret; D A Evans; D M Grant; D W Hein; H J Lin; U A Meyer; M V Relling Journal: Pharmacogenetics Date: 1995-02
Authors: Rami Nasr; Sally Temraz; Deborah Mukherji; Ali Shamseddine; Reem Akika; Sehrish Abbasi; Raja Khauli; Muhammad Bulbul; Hani Tamim; Nathalie K Zgheib Journal: Asian Pac J Cancer Prev Date: 2017-09-27